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dc.contributor.authorWaugh, David G.*
dc.contributor.authorHussain, Issam*
dc.contributor.authorLawrence, Jonathan*
dc.contributor.authorSmith, Graham C.*
dc.contributor.authorToccaceli, Christina*
dc.date.accessioned2016-06-02T14:12:35Z
dc.date.available2016-06-02T14:12:35Z
dc.date.issued2016-05-16
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/611570/stem_cell_CO2_DGW_V14_Final_revised.pdf?sequence=10
dc.identifier.citationWaugh, D. G., Hussain, I., Lawrence, J., Smith, G. C., & Toccaceli, C. (2016). In vitro mesenchymal stem cell response to a CO2 laser modified polymeric material. Materials Science and Engineering: C, 67(1), 727-736. DOI: 10.1016/j.msec.2016.05.055en
dc.identifier.issn0928-4931en
dc.identifier.doi10.1016/j.msec.2016.05.055
dc.identifier.urihttp://hdl.handle.net/10034/611570
dc.description.abstractWith an ageing world population it is becoming significantly apparent that there is a need to produce implants and platforms to manipulate stem cell growth on a pharmaceutical scale. This is needed to meet the socio-economic demands of many countries worldwide. This paper details one of the first ever studies in to the manipulation of stem cell growth on CO2 laser surface treated nylon 6,6 highlighting its potential as an inexpensive platform to manipulate stem cell growth on a pharmaceutical scale. Through CO2 laser surface treatment discrete changes to the surfaces were made. That is, the surface roughness of the nylon 6,6 was increased by up to 4.3 µm, the contact angle was modulated by up to 5° and the surface oxygen content increased by up to 1 atom%. Following mesenchymal stem cell growth on the laser treated samples, it was identified that CO2 laser surface treatment gave rise to an enhanced response with an increase in viable cell count of up to 60,000 cells/ml when compared to the as-received sample. The effect of surface parameters modified by the CO2 laser surface treatment on the mesenchymal stem cell response is also discussed along with potential trends that could be identified to govern the mesenchymal stem cell response.
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S092849311630488Xen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectCO2 laseren
dc.subjectStem cellsen
dc.subjectAdhesionen
dc.subjectWettabilityen
dc.subjectContact angleen
dc.subjectSurface engineeringen
dc.titleIn vitro mesenchymal stem cell response to a CO2 laser modified polymeric materialen
dc.typeArticleen
dc.contributor.departmentUniversity of Chester; University of Lincolnen
dc.identifier.journalMaterials Science and Engineering: C
or.grant.openaccessYesen
rioxxterms.funderUnfundeden
rioxxterms.identifier.projectUnfundeden
rioxxterms.versionAMen
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.msec.2016.05.055
rioxxterms.licenseref.startdate2017-05-16
html.description.abstractWith an ageing world population it is becoming significantly apparent that there is a need to produce implants and platforms to manipulate stem cell growth on a pharmaceutical scale. This is needed to meet the socio-economic demands of many countries worldwide. This paper details one of the first ever studies in to the manipulation of stem cell growth on CO2 laser surface treated nylon 6,6 highlighting its potential as an inexpensive platform to manipulate stem cell growth on a pharmaceutical scale. Through CO2 laser surface treatment discrete changes to the surfaces were made. That is, the surface roughness of the nylon 6,6 was increased by up to 4.3 µm, the contact angle was modulated by up to 5° and the surface oxygen content increased by up to 1 atom%. Following mesenchymal stem cell growth on the laser treated samples, it was identified that CO2 laser surface treatment gave rise to an enhanced response with an increase in viable cell count of up to 60,000 cells/ml when compared to the as-received sample. The effect of surface parameters modified by the CO2 laser surface treatment on the mesenchymal stem cell response is also discussed along with potential trends that could be identified to govern the mesenchymal stem cell response.
rioxxterms.publicationdate2016-05-16
dc.dateAccepted2016-05-15
dc.date.deposited2016-06-02


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