• The effects of a supervised cardiac rehabilitation exercise programme on left ventricular function in patients with ischaemic heart disease (interim report)

      Roberts, Elved; Fallows, Stephen; Smith, Geoffrey T. (University of Chester, 2006-08)
      Purpose. This study sought to determine the effects of a supervised cardiac rehabilitation exercise programme on left ventricular function in patients with ischaemic heart disease and any degree of left ventricular systolic dysfunction. Subjects. At the time of this interim report twelve male subjects (median age 59 years, interquartile range 56 – 67.75) and five female subjects (median age 70 years, interquartile range 55 - 72) have been recruited to the study. Eight patients are in the exercise group and nine in the control group. Eventually twenty patients will be required in each group for statistical significance. Methods. This is a repeated measures design. Echocardiographic measurements of left ventricular function were taken at the time of recruitment and repeated after a 6 week programme of exercise. Control group measurements were repeated after a similar period of usual care without exercise. Results. Both groups show an improvement in ejection fraction on repeated measurement but only the exercise group reaches statistical significance (median EF pre 43.0%, median EF post 58.6%, p=0.025). Neither group shows any significant difference in measures of diastolic function. Conclusion. An exercise based cardiac rehabilitation programme has a positive effect on left ventricular ejection fraction in patients with ischaemic heart disease and any degree of left ventricular systolic dysfunction. There is no effect on diastolic function. It remains to be seen if these findings are maintained at the end of recruitment.