• The Effects of cis-9, trans-11 Conjugated Linoleic Acid on the Proliferation of A431 Epidermoid Carcinoma Cells

      Mushtaq, Sohail; Griffiths, Samantha K. (University of Chester, 2018-08-31)
      Conjugated linoleic acid (CLA) is a family of 28 positional and geometrical isomers of linoleic acid (LA), found predominantly in the meat of ruminant animals. The health benefits of CLA have been widely researched, with specific interest into its anti-obesity and anti-carcinogenic properties. Conclusions from in-vivo studies have suggested that, with further research, CLA supplementation may be used in conjunction with current treatments for breast cancer and rectal cancer. In-vitro research into the anticarcinogenic effects of CLA has revealed that different CLA isomers affect cancer cells through several different pathways. The anti-proliferative effects of cis-9, trans-11 CLA and trans-10, cis-12 CLA have been demonstrated in-vitro, specifically on colon cancer, breast cancer, and prostate cancer. Ultimately, it has been concluded that the antiproliferative effects of CLA isomers are dependent upon the type and malignancy of the cancer cells targeted. After reviewing the literature, it is clear that there is a gap in the research. To our knowledge, no study has ever tested the effects of CLA on the proliferation of epidermoid carcinoma cells, specifically the cis-9, trans-11 CLA isomer. This research could add to the growing body of evidence surrounding the effects of specific CLA isomers on different types of cancer in-vitro.