• The National Bowel Cancer Screening Programme in Cheshire and Merseyside: Perspectives of people with a sensory impairment

      Powell, Katie; Perry, Catherine; Thurston, Miranda; University of Chester, Centre for Public Health Research (University of Chester, 2008-03)
      An report is an exploration into the accessibility of the National Bowel Cancer Screening Programme for those with a sensory impairment. The aim of the research was to explore the experiences, perceptions and understandings of people with a sensory impairment of the first stage of the screening process, from invitation to participate, to completion of a faecal occult blood test.
    • The National Health School Standard: the development of the Cheshire health and education partnership: A case study

      Thurston, Miranda (Centre for Public Health Research, Chester College of Higher Education, 2002-10)
      This project report discusses the question - what is the evidence that the Cheshire healthy schools programme is a 'partnership' based in health and education? The development of the 'partnership' and key achivements and the perceptions of 'partnership working' across the health and education sectors is analysed.
    • The National Healthy Schools Programme: A vehicle for school improvement? Case studies from Cheshire

      Thurston, Miranda (Centre for Public Health Research, University of Chester, 2006-10)
      This project report discusses the relationship between healthy school status and school improvement using case studies of three primary schools at different stages of the involvement with the healthy schools programme.
    • The natural history of the College campus

      Ing, Bruce (Governors of Chester College, 1989)
      This chapter discusses the buildings, gardens, trees, sports fields and the marginal areas of disturbed or undisturbed or undeveloped land on the Chester College campus.
    • The nature and practice of primary physical education: A study of the perceptions of subject leaders

      Green, Ken; Jones, Luke (University of Chester, 2015-09)
      Much of the existing research on primary physical education (PE) has focused on the supposed importance and potential of the subject at this age range, rather than on its actual nature and practice. It is repeatedly claimed within the literature that the development of movement skills during early learning experiences is significant as it lays the foundation for continuing participation in health enhancing physical activity. While much of the existing research has focused on the supposed importance of primary PE, further study in this area expresses concerns about the deficiencies in the preparation of primary generalists to teach the subject; over the quality of learning and teaching within the subject; and over a perceived lack of investment (in the long term) in the primary age phase. In the light of the comparatively limited research relating to primary PE, the reported issues which surround the provision of the subject and the current emphasis on its promotion through the PE and Sport Premium, the study aimed to examine change alongside continuity in what has been identified, rhetorically at least, as an important area of PE. Drawing upon data gathered from one-to-one interviews with 36 subject leaders (SLs), this study sought to describe and explain the nature and practice of primary PE and develop a more adequate understanding of what is actually happening in the name of the subject. The analysis of primary PE was undertaken through the use of a case study of one School Sport Partnership (SSP) in the north-west of England, with the theoretical framework for this study being formed by the figurational sociological perspective. The findings revealed that the most common model for the delivery of PE involved responsibility being shared between the generalist class teacher and either a sports coach or specialist PE teacher. The SLs recognised strengths and weaknesses in all of the three main approaches used. However, while they favoured the use of specialist teachers because of their subject knowledge and expertise, the more prosaic constraints of cost and flexibility meant that the use of coaches had become increasingly popular. Whether or not, the growth of coaches is de-professionalizing the delivery of PE, it certainly appears to be exacerbating any existing tendency to turn primary PE into a pale imitation of the sport-biased curricular of secondary schools. Ironically, the apparent ‘threat’ to the status of PE in the primary curriculum (as well as the status of PE specialists) posed by the growth of coaches in curricular PE in primary schools may well be exaggerated by the primary PE and Sport Premium which appears to have added momentum to a change of direction regarding staffing the subject – towards sports coaches and away from generalist classroom teachers and PE specialists. The data also showed that while the pedagogical approaches adopted in primary PE lessons did include some inclusive and developmentally appropriate methods, the overriding focus was on didactic teaching approaches being used to achieve narrow skills based outcomes. The historical dominance of games, the inclusion of primary teachers in lengthening chains of interdependence with sporting groups and individuals, and the conflation of sport with PE were all thought to have influenced the adoption of a teaching model that is unduly influenced by sport. It was also clear from SLs responses, that the prevalence of teaching methods that bind didactic and skill based pedagogy are unlikely to be challenged by the greater inclusion of sports coaches within primary PE. Finally, the contents of primary PE lessons were shown, by the data, to be dominated by sport and traditional team games; and to be organised around the timings of the major inter-school competitions and tournaments. Overall it was argued that the portents of a future with sports coaches as the main deliverers of primary ‘sport’ lessons are there for all to see, and that this apparent change is best understood by locating the subject leaders of PE in the networks of interdependent relationships that they have with others.
    • Neuromuscular function after exercise-induced muscle damage: Theoretical and applied implications

      Byrne, Christopher; Twist, Craig; Eston, Roger; DSO National Laboratories, Republic of Singapore ; NEWI/University of Wales, Bangor ; University of Wales, Bangor (Adis, 2004)
      Exercise-induced muscle damage is a well documented phenomenon particularly resulting from eccentric exercise. When eccentric exercise is unaccustomed or is performed with an increased intensity or duration, the symptoms associated with muscle damage are a common outcome and are particularly associated with participation in athletic activity. Muscle damage results in an immediate and prolonged reduction in muscle function, most notably a reduction in force-generating capacity, which has been quantified in human studies through isometric and dynamic isokinetic testing modalities. Investigations of the torque-angular velocity relationship have failed to reveal a consistent pattern of change, with inconsistent reports of functional change being dependent on the muscle action and/or angular velocity of movement. The consequences of damage on dynamic, multi-joint, sport-specific movements would appear more pertinent with regard to athletic performance, but this aspect of muscle function has been studied less often. Reductions in the ability to generate power output during single-joint movements as well as during cycling and vertical jump movements have been documented. In addition, muscle damage has been observed to increase the physiological demand of endurance exercise and to increase thermal strain during exercise in the heat. The aims of this review are to summarise the functional decrements associated with exercise-induced muscle damage, relate these decrements to theoretical views regarding underlying mechanisms (i.e. sarcomere disruption, impaired excitation-contraction coupling, preferential fibre type damage, and impaired muscle metabolism), and finally to discuss the potential impact of muscle damage on athletic performance.
    • Neuropsychiatric symptoms following metal-on-metal implant failure with cobalt and chromium toxicity

      Green, Ben; Griffiths, Emily; Almond, Solomon; University of Chester; Public Health England (BioMed Central, 2016-01-24)
      Background: There were at least 31,171 metal-on-metal (MoM) hip implants in the UK between 2003 and 2011. Some of these were subject to failure and widescale recalls and revisions followed. Method This is a presentation of ten cases (mean age 60 years) where we evaluated neuropsychiatric morbidity following metal-on-metal hip implant failure and revision. Implants were ASR total hip replacement (acetabular implant, taper sleeve adaptor and unipolar femoral implants) performed between 2005 and 2009. This case series describes, for the first time, neuropsychiatric complications after revision where there has been cobalt and chromium toxicity. Results Pre-revision surgery, nine patients had toxic levels of chromium and cobalt (mean level chromium 338 nmol/l, mean cobalt 669.4 nmol/l). Depression assessment showed 9 of 9 respondents fulfilled the BDI criteria for depression and 3 of these were being treated. 7 of 9 patients showing short term memory deficit with mean mini mental state examination score of 24.2. The normal population mean MMSE for this group would be expected to be 28 with <25 indicating possible dementia. Conclusions We found neurocognitive and depressive deficits after cobalt and chromium metallosis following MoM implant failure. Larger studies of neurocognitive effects are indicated in this group. There may be implications for public health.
    • Nicholaus Steno - the blessed (1638-1686)

      Burek, Cynthia V. (Earth Science Teachers' Association, 2005)
      This article discusses the life and career of Nicholaud Steno (1638-1686).
    • Nicotinamide alone accelerates the conversion of mouse embryonic stem cells into mature neuronal populations.

      Griffin, Sile M.; Pickard, Mark R.; Orme, Rowan P.; Hawkins, Clive P.; Williams, Adrian C.; Fricker, Rosemary A.; Keele University; University of Chester; University Hospital of North Staffordshire; University of Birmingham (Public Library of Science, 2017-08-17)
      Vitamin B3 has been shown to play an important role during embryogenesis. Specifically, there is growing evidence that nicotinamide, the biologically active form of vitamin B3, plays a critical role as a morphogen in the differentiation of stem cells to mature cell phenotypes, including those of the central nervous system (CNS). Detailed knowledge of the action of small molecules during neuronal differentiation is not only critical for uncovering mechanisms underlying lineage-specification, but also to establish more effective differentiation protocols to obtain clinically relevant cells for regenerative therapies for neurodegenerative conditions such as Huntington's disease (HD). Thus, this study aimed to investigate the potential of nicotinamide to promote the conversion of stem cells to mature CNS neurons. METHODS: Nicotinamide was applied to differentiating mouse embryonic stem cells (mESC; Sox1GFP knock-in 46C cell line) during their conversion towards a neural fate. Cells were assessed for changes in their proliferation, differentiation and maturation; using immunocytochemistry and morphometric analysis methods. RESULTS: Results presented indicate that 10 mM nicotinamide, when added at the initial stages of differentiation, promoted accelerated progression of ESCs to a neural lineage in adherent monolayer cultures. By 14 days in vitro (DIV), early exposure to nicotinamide was shown to increase the numbers of differentiated βIII-tubulin-positive neurons. Nicotinamide decreased the proportion of pluripotent stem cells, concomitantly increasing numbers of neural progenitors at 4 DIV. These progenitors then underwent rapid conversion to neurons, observed by a reduction in Sox 1 expression and decreased numbers of neural progenitors in the cultures at 14 DIV. Furthermore, GABAergic neurons generated in the presence of nicotinamide showed increased maturity and complexity of neurites at 14 DIV. Therefore, addition of nicotinamide alone caused an accelerated passage of pluripotent cells through lineage specification and further to non-dividing mature neurons. CONCLUSIONS: Our results show that, within an optimal dose range, nicotinamide is able to singly and selectively direct the conversion of embryonic stem cells to mature neurons, and therefore may be a critical factor for normal brain development, thus supporting previous evidence of the fundamental role of vitamins and their metabolites during early CNS development. In addition, nicotinamide may offer a simple effective supplement to enhance the conversion of stem cells to clinically relevant neurons.
    • No difference in satiety or in subsequent energy intakes between a beverage and a solid food

      Almiron-Roig, Eva; Flores, Sonia Y.; University of Washington (Elsevier, 2004-09)
      Energy compensation following the consumption of caloric beverages is said to be imprecise and incomplete. This study compared the relative impact on satiety and energy intakes of the physical form of foods versus the timing of consumption. Thirty-two volunteers (16 men and 16 women), aged 18–35 years, consumed equal-energy preloads (1254 kJ, 300 kcal) of regular cola (710 ml, 24 oz) or fat-free raspberry cookies (87 g, 3 oz) on two occasions each. The preloads were presented either 2 h or 20 min before the test meal. Their principal ingredient was sugar. Participants rated motivational states prior to ingestion and at 30-min intervals. A tray lunch was presented at 12:30 p.m., and food consumption was measured. Regular cola and cookies suppressed hunger ratings equally and no temporal difference in satiety was observed. Cola, but not cookies, resulted in lower ratings of thirst. Energy intakes at lunch were lower when the preload was consumed closer to the test meal (20 min) but was not affected by physical form (liquid vs. solid). Cola, but not cookies, reduced water intakes at lunch. There was no satiety deficit following the ingestion of a beverage as compared with a solid food. The timing of consumption may be more important than the physical form of energy consumed.
    • No Effect of Beetroot Juice Supplementation on 100-m and 200-m Swimming Performance in Moderately-Trained Swimmers.

      Esen, Ozcan; Nicholas, Ceri; Morris, Mike; Bailey, Stephen J (2018-11-14)
      Dietary nitrate supplementation has been reported to improve performance in kayaking and rowing exercise which mandate significant recruitment of the upper body musculature. Since the effect of dietary nitrate supplementation on swimming performance is unclear, the purpose of this study was to assess the effect of dietary nitrate supplementation on 100-m and 200-m swimming freestyle time-trial (TT) performance. In a double blind, randomized crossover design, ten moderately-trained swimmers underwent two separate 3-day supplementation periods, with a daily dose of either 140 mL nitrate-rich (BRJ; ~800 mg/d nitrate) or nitrate-depleted (PLA) BRJ. Following blood sampling on day 3, the swimmers performed both 200-m and 100-m freestyle swimming TTs, with 30 min recovery between trials. Plasma nitrite concentrations was greater after BRJ relative to PLA consumption (432 ± 203 nmol/L, 111 ± 56 nmol/L, respectively, p = 0.001). Systolic BP was lowered after BRJ compared to PLA supplementation (114 ± 10, 120 ± 10 mmHg, respectively p = 0.001), but time to complete the 200-m (BRJ: 152.6 ± 14.1 s, PLA: 152.5 ± 14.1 s) and 100-m (BRJ: 69.5 ± 7.2 s, PLA: 69.4 ± 7.4 s) freestyle swimming TTs were not different between BRJ and PLA (p > 0.05). While 3 days of BRJ supplementation increased plasma nitrite concentration and lowered blood pressure, it did not improve 100-m and 200-m swimming TT performance. These results do not support an ergogenic effect of nitrate supplementation in moderately-trained swimmers, at least for 100-m and 200-m freestyle swimming performance.
    • ‘No pain, no gain’: former elite female gymnasts’ engagements with pain and injury discourses

      Tynan, Ruby; McEvilly, Nollaig; University of Chester (Taylor & Francis, 2017-05-11)
      This paper investigates former elite female gymnasts’ views and experiences of pain and injury. The purpose of the study was to examine how participants engaged with pain and injury discourses and interrogate the ways in which certain knowledge and practices had become dominant. A Foucaultian theoretical framework underpinned the study, making use of Foucault’s work on discourses, power and resistance. Data were generated through semi-structured interviews with seven former elite gymnasts. By analysing the participants’ talk through poststructural discourse analysis, three themes were identified. Firstly, participants’ persistence through pain and injury was due to the desire to compete. Secondly, participants differentiated between ‘good pain’ and ‘bad pain’. Thirdly, participants had a higher tolerance for pain than for injury. This research raises questions about the dominance of a ‘no pain, no gain’ discourse, and the ways in which gymnasts may develop an uncritical acceptance of particular ‘truths’ surrounding pain and injury.
    • Non-invasive tools to quantify hypothalamic-pituitary function in lion-tailed macaques (Macaca silenus)

      Skyner, Lindsay J.; Smith, Tessa E.; University College Chester (Karger, 2004)
    • Not just making babies: A Darwinian perspective

      Lewis, Stephen J.; Chester College of Higher Education (2009-11-25)
    • Novel anti-oxidant properties of cobalamin

      Williams, John H. H.; Andrew, Sarah M.; Altaie, Ala (University of Liverpool (University of Chester), 2009-09)
      Oxidative stress has been associated with a wide range of diseases, including cardiovascular diseases, Alzheimer's disease, atherosclerosis, Parkinson's disease and cancer. It also plays a role in the ageing process. Hyperhomocysteimia is commonly found to be associated with these diseases. The hyperhomocysteimia is a result of a deficiency in both folate and cobalamin Folate is known to reduce Hey and protect cells from apoptosis, but there are no studies investigating the impact of cobalamin on apoptosis induced by oxidative stress or the mechanism(s) of the protection. The aims of the research are to investigate the protective role of cobalamin and the possible mechanism(s) for this protection. It also examines the protective role of novel cobalamin and investigates their superior protection. The methods used in this research for apoptosis detection we used caspase-3 and the annexin-V, while for necrosis we used PI staining, where cell viability were detected using MTS assay. We also measured the generation of superoxide by Lucigenin-enhanced chemiluminescence and reactive oxygene species by using the redox active prob DCFH-DA. Moreover, the intracellular proteins were measured via staining with specific fluorescent-conjugated antibodies were detected using flowcytometry. Our result demonstrated that 25|iM of cobalamin protects cells from apoptosis. The protection by cobalamin was associated with induction of iHsp72 and iHO-1, and these are shown to be essential for the protection. Furthermore, our research demonstrated a novel mechanism of cobalamin-apoptosis protection involving induction of NfkB, ERK1/2 and AKT signal transduction pathways. In order to protect cells from apoptosis induced by oxidative stress, cobalamin induces the pNfkB which in turn regulate the iNOS and HO-1 induction. Cobalamin also induces thepERK1/2 which regulates the induction of Hps72 and Nrf2. And finally, pAKT induced by cobalamin which regulate the Nrf2 and HO-1 induction. The inhibition of any of theses pathways leads to loss the protection. The GSCbl and NACCbl provide a superior protection against oxidative stress, this protection involved induction of the signal transduction pathways and Hsps. To conclude; cobalamin provides protection against cells death induced by oxidative stress. Cobalamin achieves this by multiple pathways which include direct antioxidant stimulation and induction of signal transduction pathways. Different cobalamin derivatives have superior protections. These finding are a useful pharmaceutical tool in the treatment of the oxidative stress related diseases.
    • The number of directional changes alters the physiological, perceptual and neuromuscular responses of netball players during intermittent shuttle running

      Ashton, Ruth; Twist, Craig; University of Chester (Lippincott, Williams & Wilkins, 2015-03-11)
      This study investigated whether an increased number of changes in direction altered the metabolic, cardiovascular, perceptual and neuromuscular responses to intermittent shuttle running. Using a randomized crossover design, ten female netball players completed 30 min of intermittent shuttle running over a 10 m (ISR10) and 20 m (ISR20) linear course. Measures of expired air, heart rate (HR), RPE, blood lactate concentration ([BLa]) and peak torque of knee extensors and flexors were measured. Differences (% ± 90% CL) in VO2 (1.5 ± 5.6%) was unclear between conditions, while HR was possibly higher (1.5 ± 2.5%) and [BLa] very likely lower in ISR20 compared to ISR10 (-32.7 ± 9.9%). RPE was likely lower in the ISR20 compared to the ISR10 condition at 15 (-5.0 ± 5.0%) and mosly likely lower at 30 min (-9.4 ± 2.0%). Sprint times over 20 m were likely slower during ISR20 at mid (3.9 ± 3.2%) but unclear post (2.1 ± 5.4%). Changes in muscle function were not different between ISR10 and ISR20 conditions for knee extension (-0.2 ± 0.9%) but were likely different for knee flexion (-5.7 ± 4.9%). More directional changes during shuttle running increases the physiological and perceptual load on female athletes that also causes a greater reductions in knee extensor torque. These findings have implications for the effective conditioning and injury prevention of female team sport athletes.
    • The nurse practitioner in primary care: Alleviating problems of access?

      Perry, Catherine; Thurston, Miranda; Killey, Mona; Miller, Julia; University of Chester ; University of Chester ; University of Chester ; Halton Primary Care Trust (Mark Allen Publishing, 2005)
      Improving access to primary care services is an essential component of the NHS modernization plan and the advent of independent nurse practitioners in primary care has focused attention on the extent to which this group of nurses can effectively substitute for GPs. This study was designed to explore the role of a nurse practitioner in primary care, particularly whether the provision of a nurse practitioner facilitated access to care that met the needs of patients. Semistructured interviews were conducted with 14 patients who had consulted with the nurse practitioner, 10 staff within the practice who had knowledge of the role, and the nurse practitioner herself. With the permission of interviewees, interviews were audiotaped, the tapes transcribed verbatim, and the data were coded by theme. It was perceived by both groups of interviewees that access to care had been improved in that there were more appointments available, appointments were longer than they had been previously and were available at different times of the day. However, some areas in which access was 'restricted' were articulated by staff interviewees, such as limitations to the nurse practitioner's prescribing and problems with referring patients to secondary care. Additionally, while access to a member of the primary healthcare team was improved for many patients, access to a specific member of the team, such as a GP, was not always improved. Concerns were also expressed about how the role of the nurse practitioner needed to be developed in the practice. It can be concluded from this study that, potentially, the role of nurse practitioner has much to offer in terms of addressing problems of access in primary care for some patients. However, this is not a straightforward solution and in order for the role to be effective several issues highlighted in this study require addressing.
    • Obesity and health: Understanding the issues in Pakistani women living in the UK

      Ludwig, Alison F.; Ellahi, Basma; Cox, Peter; University of Chester (British Sociological Association, 2008)
    • The observational analysis of elite coaches within youth soccer: The importance of performance analysis

      Nicolls, Scott B.; Worsfold, Paul R.; University of Chester; Middlesex University; Manchester Institute of Health and Performance (SAGE, 2016-11-15)
      The study investigated the observational capabilities of experienced elite coaches whilst focusing upon soccer specific actions and playing positions within elite youth soccer. Six soccer coaches assessed the performances of 10 youth soccer players (across 8 matches) on their short/long passing, tackling, shooting, heading and dribbling. Analysis was undertaken on an overall, quality and positional grouping basis. Mean observational accuracy was 38.8%, with successful shooting (78.6%) and passing (29.9%) illustrating the range. The limited effective observation of dribbling (37.2%), often considered a separating factor within talent identification, highlights the need for objective measures to aid such processes. Positional grouping analysis elicited 20% more effective observation for unsuccessful compared with successful actions. The poor level of observational accuracy identified herein has significant implications on talent identification assessments devoid of post-performance analyses. The findings reinforce the importance of performance analysis in the provision of highly accurate and comprehensive augmented feedback within the coaching process.
    • Oesophageal stenting: Status quo and future challenges.

      Kaltsidis, Harry; Mansoor, Wasat; Park, Jung-Hoon; Song, Ho-Young; Edwards, Derek William; Laasch, Hans-Ulrich; orcid: 0000-0003-3109-6933 (2018-06-11)
      Oesophageal stents are widely used for palliating dysphagia from malignant obstruction. They are also used with increasing frequency in the treatment of oesophageal perforation, as well as benign strictures from a variety of causes. Improved oncological treatments have led to prolonged survival of patients treated with palliative intent; as a consequence, stents need to function and last longer in order to avoid repeat procedures. There is also increasing need for meticulous procedure planning, careful selection of the device most appropriate for the individual patient and planned follow-up. Furthermore, as more patients are cured, there will be more issues with resultant long-term side-effects, such as recalcitrant strictures due to radiotherapy or anastomotic scarring, which will have to be addressed. Stent design needs to keep up with the progress of cancer treatment, in order to offer patients the best possible long-term result. This review article attempts to illustrate the changing realities in oesophageal stenting, differences in current stent designs and behaviour, as well as the pressing need to refine and modify devices in order to meet the new challenges.