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The influence of different work and rest distributions on performance and fatigue during simulated team handball match playThis study investigated the effect of different interchange strategies on performance and pacing strategy during a simulated team-sports protocol. Eight youth male team handball players completed two conditions (LONG; work: 3 x 13:00 min, rest: 8:00 min, SHORT; work: 5 x 7:48 min, rest: 3:45 min). Participants were tested for 20 m sprint, counter-movement jump, throwing performance and heart rate during conditions. Postcondition measures included repeated shuttle-sprint and jump ability, session rating of perceived exertion, blood lactate and glucose. Faster sprint (3.87 ± 0.27 s cf. 3.97 ± 0.24 s, ES = 0.39, P= 0.03) and throwing performance (70.02 ± 7.40 km*h-1 cf. 69.04 ± 5.57 km*h-1, P> 0.05, ES = -0.15) occurred in SHORT compared to LONG by a 'likely small' difference. Higher summated heart rate (157 ± 21 cf. 150 ± 15 AU) occurred in SHORT compared to LONG by a 'likely small' difference (ES = 0.37, P> 0.05). SHORT resulted in lower session rating of perceived exertion (224 ± 45 AU cf. 282 ± 35 AU, ES = 1.45, P= 0.001) and higher blood glucose (6.06 ± 0.69 mmol*l-1 cf. 4.98 ± 1.10 mmol*l-1, ES = -1.17, P= 0.03) by a 'most likely moderate' difference compared to LONG. Repeated shuttle-sprint was better preserved after SHORT, with 'moderately lower' 10 m and 25 m times (P< 0.05). Interchange strategies using SHORT rather than LONG work and rest periods result in lower physiological load, leading to improved fatigue resistance and better preservation of high-intensity movements during matches.