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dc.contributor.authorSaunders, Philippa M.*
dc.contributor.authorVivian, Julian P.*
dc.contributor.authorO'Connor, Geraldine M.*
dc.contributor.authorSullivan, Lucy C.*
dc.contributor.authorPymm, Phillip*
dc.contributor.authorRossjohn, Jamie*
dc.contributor.authorBrooks, Andrew G.*
dc.date.accessioned2016-03-30T15:57:39Z
dc.date.available2016-03-30T15:57:39Z
dc.date.issued2015-09
dc.identifier.citationSaunders, P. M., Vivian, J. P., O'Connor, G. M., Sullivan, L. C., Pymm, P., Rossjohn, J., & Brooks, A. G. (2015). A bird's eye view of NK cell receptor interactions with their MHC class I ligands. Immunological Reviews, 267(1), 148-166. doi: 10.1111/imr.12319
dc.identifier.doi10.1111/imr.12319
dc.identifier.urihttp://hdl.handle.net/10034/604029
dc.descriptionThis is the peer reviewed version of the following article:Saunders, P. M., Vivian, J. P., O'Connor, G. M., Sullivan, L. C., Pymm, P., Rossjohn, J., & Brooks, A. G. (2015). A bird's eye view of NK cell receptor interactions with their MHC class I ligands. Immunological Reviews, 267(1), 148-166. doi: 10.1111/imr.12319 , which has been published in final form athttp://onlinelibrary.wiley.com/doi/10.1111/imr.12319/full . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
dc.description.abstractThe surveillance of target cells by natural killer (NK) cells utilizes an ensemble of inhibitory and activating receptors, many of which interact with major histocompatibility complex (MHC) class I molecules. NK cell recognition of MHC class I proteins is important developmentally for the acquisition of full NK cell effector capacity and during target cell recognition, where the engagement of inhibitory receptors and MHC class I molecules attenuates NK cell activation. Human NK cells have evolved two broad strategies for recognition of human leukocyte antigen (HLA) class I molecules: (i) direct recognition of polymorphic classical HLA class I proteins by diverse receptor families such as the killer cell immunoglobulin-like receptors (KIRs), and (ii) indirect recognition of conserved sets of HLA class I-derived peptides displayed on the non-classical HLA-E for recognition by CD94-NKG2 receptors. In this review, we assess the structural basis for the interaction between these NK receptors and their HLA class I ligands and, using the suite of published KIR and CD94-NKG2 ternary complexes, highlight the features that allow NK cells to orchestrate the recognition of a range of different HLA class I proteins.
dc.language.isoen_USen
dc.subjectNatural Killer Cellsen
dc.subjectKIRen
dc.titleA bird's eye view of NK cell receptor interactions with their MHC class I ligands.en_US
dc.typeArticleen
dc.identifier.journalImmunological Reviewsen
refterms.dateFOA2016-10-01T00:00:00Z
html.description.abstractThe surveillance of target cells by natural killer (NK) cells utilizes an ensemble of inhibitory and activating receptors, many of which interact with major histocompatibility complex (MHC) class I molecules. NK cell recognition of MHC class I proteins is important developmentally for the acquisition of full NK cell effector capacity and during target cell recognition, where the engagement of inhibitory receptors and MHC class I molecules attenuates NK cell activation. Human NK cells have evolved two broad strategies for recognition of human leukocyte antigen (HLA) class I molecules: (i) direct recognition of polymorphic classical HLA class I proteins by diverse receptor families such as the killer cell immunoglobulin-like receptors (KIRs), and (ii) indirect recognition of conserved sets of HLA class I-derived peptides displayed on the non-classical HLA-E for recognition by CD94-NKG2 receptors. In this review, we assess the structural basis for the interaction between these NK receptors and their HLA class I ligands and, using the suite of published KIR and CD94-NKG2 ternary complexes, highlight the features that allow NK cells to orchestrate the recognition of a range of different HLA class I proteins.


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