Manipulation of glycemic response with isomaltulose in a milk-based drink does not affect cognitive performance in healthy adults
Authors
Dye, LouiseGilsenan, Mary B.
Quadt, Frits
Martens, Vanessa E. G.
Bot, Arjen
Lasikiewicz, Nicola
Camidge, Diana
Croden, Fiona
Lawton, Clare
Publication Date
2010-04-07
Metadata
Show full item recordAbstract
Previous research suggests that glucoregulation and nutrient interventions, which alter circulating glucose, impact cognitive function. To examine the effect of modulating glycemic response using isomaltulose on cognitive function 24 healthy male adult participants consumed energy and macronutrient-matched milk-based drinks containing 50 g isomaltulose, 50 g sucrose or a water control in a counterbalanced within-subject design. Interstitial glucose was measured continuously in 12 subjects and all provided 9 capillary measures on each test day. A 30-min cognitive test battery was administered before and twice (+35 and +115 min) after drink ingestion. Immediate, delayed, recognition, verbal and working memory, and psychomotor performance were assessed. Glycemic profiles induced by the drinks differed significantly during the first but not the second post-drink test battery. Neither administration of the sucrose nor isomaltulose drinks produced consistent effects on verbal or working memory, or psychomotor performance. This study used isomaltulose as an investigative tool to lower glycemic response. Importantly, it demonstrates a lack of effect of modulating glucose on cognitive performance based on reliable, continuously measured glycemia. It refutes the hypothesis that glycemia is associated with cognitive performance and questions the suggestion that isomaltulose has an effect on cognitive performance.Citation
Manipulation of glycemic response with isomaltulose in a milk-based drink does not affect cognitive performance in healthy adults (2010) Molecular Nutrition & Food Research, 54(4), 506Publisher
WileyAdditional Links
http://doi.wiley.com/10.1002/mnfr.200900196Type
ArticleLanguage
enISSN
1613412516134133
ae974a485f413a2113503eed53cd6c53
10.1002/mnfr.200900196