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    Model-directed engineering of “difficult-to-express” monoclonal antibody production by Chinese hamster ovary cells

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    Authors
    Pybus, Leon P.
    Dean, Greg
    West, Nathan R.
    Smith, Andrew
    Daramola, Olalekan
    Field, Ray
    Wilkinson, Stephen J.
    James, David C.
    Affiliation
    University of Sheffield ; BioPharmaceutical Development ; University of Sheffield ; BioPharmaceutical Development ; BioPharmaceutical Development ; BioPharmaceutical Development ; University of Sheffield ; University of Sheffield
    Publication Date
    2013-11-14
    
    Metadata
    Show full item record
    Abstract
    Despite improvements in volumetric titer for monoclonal antibody (MAb) production processes using Chinese hamster ovary (CHO) cells, some “difficult-to-express” (DTE) MAbs inexplicably reach much lower process titers.
    Citation
    Model-directed engineering of “difficult-to-express” monoclonal antibody production by Chinese hamster ovary cells. Biotechnology and Bioengineering, 2014, 111(2), pp. 372-385
    Publisher
    Wiley
    Journal
    Biotechnology and Bioengineering
    URI
    http://hdl.handle.net/10034/552294
    DOI
    10.1002/bit.25116
    Additional Links
    http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0290
    http://doi.wiley.com/10.1002/bit.25116
    Type
    Article
    Language
    en
    Description
    This article is not available through ChesterRep.
    ISSN
    0006-3592
    ae974a485f413a2113503eed53cd6c53
    10.1002/bit.25116
    Scopus Count
    Collections
    Chemical Engineering

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