Model-directed engineering of “difficult-to-express” monoclonal antibody production by Chinese hamster ovary cells

Authors
Pybus, Leon P.
Dean, Greg
West, Nathan R.
Smith, Andrew
Daramola, Olalekan
Field, Ray
Wilkinson, Stephen J.
James, David C.
Affiliation
University of Sheffield ; BioPharmaceutical Development ; University of Sheffield ; BioPharmaceutical Development ; BioPharmaceutical Development ; BioPharmaceutical Development ; University of Sheffield ; University of Sheffield
Publication Date
2013-11-14

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Abstract
Despite improvements in volumetric titer for monoclonal antibody (MAb) production processes using Chinese hamster ovary (CHO) cells, some “difficult-to-express” (DTE) MAbs inexplicably reach much lower process titers.
Citation
Model-directed engineering of “difficult-to-express” monoclonal antibody production by Chinese hamster ovary cells. Biotechnology and Bioengineering, 2014, 111(2), pp. 372-385
Publisher
Wiley
Journal
Biotechnology and Bioengineering
URI
http://hdl.handle.net/10034/552294
DOI
10.1002/bit.25116
Additional Links
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0290
http://doi.wiley.com/10.1002/bit.25116
Type
Article
Language
en
Description
This article is not available through ChesterRep.
ISSN
0006-3592
Collections
Chemical Engineering