Model-directed engineering of “difficult-to-express” monoclonal antibody production by Chinese hamster ovary cells
Authors
Pybus, Leon P.Dean, Greg
West, Nathan R.
Smith, Andrew
Daramola, Olalekan
Field, Ray
Wilkinson, Stephen J.
James, David C.
Affiliation
University of Sheffield ; BioPharmaceutical Development ; University of Sheffield ; BioPharmaceutical Development ; BioPharmaceutical Development ; BioPharmaceutical Development ; University of Sheffield ; University of SheffieldPublication Date
2013-11-14
Metadata
Show full item recordAbstract
Despite improvements in volumetric titer for monoclonal antibody (MAb) production processes using Chinese hamster ovary (CHO) cells, some “difficult-to-express” (DTE) MAbs inexplicably reach much lower process titers.Citation
Model-directed engineering of “difficult-to-express” monoclonal antibody production by Chinese hamster ovary cells. Biotechnology and Bioengineering, 2014, 111(2), pp. 372-385Publisher
WileyJournal
Biotechnology and BioengineeringAdditional Links
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0290http://doi.wiley.com/10.1002/bit.25116
Type
ArticleLanguage
enDescription
This article is not available through ChesterRep.ISSN
0006-3592ae974a485f413a2113503eed53cd6c53
10.1002/bit.25116