Affiliation
University of Chester ; Liverpool Hope University ; Edge Hill University ; University of ChesterPublication Date
2015-04-27
Metadata
Show full item recordAbstract
The underlying cellular mechanisms that characterize aging are complex and multifaceted. However, it is emerging that aging could be regulated by two distinct metabolic hubs. These hubs are the pathway defined by the mammalian target of rapamycin (mTOR) and that defined by the NAD+-dependent deacetylase enzyme, SIRT1. Recent experimental evidence suggests that there is crosstalk between these two important pathways; however, the mechanisms underpinning their interaction(s) remains poorly understood. In this review, we propose using computational modelling in tandem with experimentation to delineate the mechanism(s). We briefly discuss the main modelling frameworks that could be used to disentangle this relationship and present a reduced reaction pathway that could be modelled. We conclude by outlining the limitations of computational modelling and by discussing opportunities for future progress in this area.Citation
Mc Auley, M. T., Mooney, K. M., Angell, P. J., & Wilkinson, S. J. (2015). Mathematical modelling of metabolic regulation in aging. Metabolites, 5(2), 232-251.Publisher
MDPIJournal
MetabolitesType
ArticleLanguage
enISSN
2218-1989ae974a485f413a2113503eed53cd6c53
10.3390/metabo5020232
Scopus Count
Collections
The following license files are associated with this item: