AffiliationUniversity of Chester ; Edge Hill University
MetadataShow full item record
AbstractComputational modelling is a key component of systems biology and integrates with the other techniques discussed thus far in this book by utilizing a myriad of data that are being generated to quantitatively represent and simulate biological systems. This chapter will describe what computational modelling involves; the rationale for using it, and the appropriateness of modelling for investigating the aging process. How a model is assembled and the different theoretical frameworks that can be used to build a model are also discussed. In addition, the chapter will describe several models which demonstrate the effectiveness of each computational approach for investigating the constituents of a healthy aging trajectory. Specifically, a number of models will be showcased which focus on the complex age-related disorders associated with unhealthy aging. To conclude, we discuss the future applications of computational systems modelling to aging research.
CitationIn A. Yashin, & S. M. Jazwinski (Eds.), Aging and health - A systems biology perspective, 40, (pp. 35-48). Karger, 2015
DescriptionThis book chapter is not available through ChesterRep.
Series/Report no.Interdisciplinary Topics in Gerontology and Geriatrics
- Computational systems biology of aging.
- Authors: Kriete A, Lechner M, Clearfield D, Bohmann D
- Issue date: 2011 Jul-Aug
- Investigating cholesterol metabolism and ageing using a systems biology approach.
- Authors: Morgan AE, Mooney KM, Wilkinson SJ, Pickles NA, Mc Auley MT
- Issue date: 2017 Aug
- Systems biology approaches in aging research.
- Authors: Chauhan A, Liebal UW, Vera J, Baltrusch S, Junghanß C, Tiedge M, Fuellen G, Wolkenhauer O, Köhling R
- Issue date: 2015
- SysBioMed report: advancing systems biology for medical applications.
- Authors: Wolkenhauer O, Fell D, De Meyts P, Blüthgen N, Herzel H, Le Novère N, Höfer T, Schürrle K, van Leeuwen I
- Issue date: 2009 May
- The road from systems biology to systems medicine.
- Authors: Wolkenhauer O, Auffray C, Jaster R, Steinhoff G, Dammann O
- Issue date: 2013 Apr