AffiliationUniversity of Chester ; Edge Hill University
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AbstractComputational modelling is a key component of systems biology and integrates with the other techniques discussed thus far in this book by utilizing a myriad of data that are being generated to quantitatively represent and simulate biological systems. This chapter will describe what computational modelling involves; the rationale for using it, and the appropriateness of modelling for investigating the aging process. How a model is assembled and the different theoretical frameworks that can be used to build a model are also discussed. In addition, the chapter will describe several models which demonstrate the effectiveness of each computational approach for investigating the constituents of a healthy aging trajectory. Specifically, a number of models will be showcased which focus on the complex age-related disorders associated with unhealthy aging. To conclude, we discuss the future applications of computational systems modelling to aging research.
CitationIn A. Yashin, & S. M. Jazwinski (Eds.), Aging and health - A systems biology perspective, 40, (pp. 35-48). Karger, 2015
DescriptionThis book chapter is not available through ChesterRep.
Series/Report no.Interdisciplinary Topics in Gerontology and Geriatrics