Prenatal exposures and exposomics of asthma
| dc.contributor.author | Choi, Hyunok | * |
| dc.contributor.author | Mc Auley, Mark T. | * |
| dc.contributor.author | Lawrence, David A. | * |
| dc.date.accessioned | 2015-03-24T11:21:06Z | |
| dc.date.available | 2015-03-24T11:21:06Z | |
| dc.date.issued | 2015-02-19 | |
| dc.identifier.citation | Choi, H., Mc Auley, M. T., & Lawrence, D. A. (2015). Prenatal exposures and exposomics of asthma. AIMS Environmental Science, 2(1), 87-109. | en |
| dc.identifier.doi | 10.3934/environsci.2015.1.87 | |
| dc.identifier.uri | http://hdl.handle.net/10034/347044 | |
| dc.description.abstract | This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental media | |
| dc.language.iso | en_US | en |
| dc.publisher | AIMS Press | en |
| dc.relation.url | http://www.aimspress.com/aimses/ch/reader/view_abstract.aspx?file_no=Environ2014015&flag=1 | en |
| dc.subject | asthma | en |
| dc.subject | mathematical modelling | en |
| dc.title | Prenatal exposures and exposomics of asthma | en |
| dc.type | Article | en |
| dc.contributor.department | University at Albany ; University of Chester ; Center for Medical Sciences, Albany, NY | en |
| dc.identifier.journal | AIMS Environmental Science | |
| rioxxterms.versionofrecord | https://doi.org/10.3934/environsci.2015.1.87 | |
| html.description.abstract | This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental media | |
| rioxxterms.publicationdate | 2015-02-19 | |
| dc.dateAccepted | 2015-02-09 | |
| dc.date.deposited | 2015-03-24 |
