AffiliationUniversity at Albany ; University of Chester ; Center for Medical Sciences, Albany, NY
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AbstractThis review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental media
CitationAIMS Environmental Science, 2015, 2(1), pp. 87-109.
JournalAIMS Environmental Science
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