Mortality in type 2 diabetes mellitus: Magnitude of the evidence from a systematic review and meta-analysis
| dc.contributor.author | Nwaneri, Chukwuemeka | * |
| dc.contributor.author | Cooper, Helen | * |
| dc.contributor.author | Bowen-Jones, David | * |
| dc.date.accessioned | 2014-11-24T11:19:55Z | en |
| dc.date.available | 2014-11-24T11:19:55Z | |
| dc.date.issued | 2013-07-15 | |
| dc.identifier.citation | British Journal of Diabetes & Vascular Disease, 2013, 13(4), pp.192-207 | |
| dc.identifier.issn | 1474-6514 | en |
| dc.identifier.doi | 10.1177/1474651413495703 | |
| dc.identifier.uri | http://hdl.handle.net/10034/336032 | |
| dc.description | This article is not available through ChesterRep. | |
| dc.description.abstract | Type 2 diabetes is associated with an increase in age-related mortality. A systematic review and metaanalysis were performed to define the relative risks (RR) of all-cause or cause-specific mortality in type 2 diabetes and to determine gaps in current research. A comprehensive literature search was undertaken for studies (published 1990–2010) on mortality in type 2 diabetes. The study reports on the measure of mortality as defined by RR for all-cause and cause-specific mortality, heterogeneity, sensitivity analyses and biases. In total 35 studies (220,689 patients; mean follow-up of 10.7 years) were eligible for inclusion: 33 studies reported increased mortality risks; 24 had full data on 95% confidence intervals (CIs), one study reported no excess mortality in men diagnosed after 65 years whereas three reported increased mortality in similar age groups in both sexes. Meta-analysis showed RR = 1.85 (95% CI 1.79–1.92) for all-cause mortality [men RR=1.57 (95% CI 1.46–1.68); women RR=2.0 (95% CI 1.89–2.12)], RR=1.76 (95% CI 1.66–1.88) for cardiovascular mortality and RR=2.26 (95% CI: 1.7-3.02) for stroke. There was no statistically significant evidence of publication bias. Conclusion: Type 2 diabetes increases mortality approximately two-fold increase and macrovascular disease is the principal cause of death. | |
| dc.language.iso | en | en |
| dc.publisher | SAGE Publications | en |
| dc.relation.url | https://journals.sagepub.com/doi/10.1177/1474651413495703 | en |
| dc.rights | Archived with thanks to The British Journal of Diabetes & Vascular Disease | en |
| dc.subject | meta-analysis | en |
| dc.subject | mortality rate | en |
| dc.subject | odds ratio | en |
| dc.subject | relative risk | en |
| dc.subject | type 2 diabetes mellitus | en |
| dc.title | Mortality in type 2 diabetes mellitus: Magnitude of the evidence from a systematic review and meta-analysis | en |
| dc.type | Article | en |
| dc.identifier.eissn | 1753-4305 | |
| dc.contributor.department | University of Chester; Alder Hey Children’s NHS Foundation Trust | |
| dc.identifier.journal | British Journal of Diabetes & Vascular Disease | |
| html.description.abstract | Type 2 diabetes is associated with an increase in age-related mortality. A systematic review and metaanalysis were performed to define the relative risks (RR) of all-cause or cause-specific mortality in type 2 diabetes and to determine gaps in current research. A comprehensive literature search was undertaken for studies (published 1990–2010) on mortality in type 2 diabetes. The study reports on the measure of mortality as defined by RR for all-cause and cause-specific mortality, heterogeneity, sensitivity analyses and biases. In total 35 studies (220,689 patients; mean follow-up of 10.7 years) were eligible for inclusion: 33 studies reported increased mortality risks; 24 had full data on 95% confidence intervals (CIs), one study reported no excess mortality in men diagnosed after 65 years whereas three reported increased mortality in similar age groups in both sexes. Meta-analysis showed RR = 1.85 (95% CI 1.79–1.92) for all-cause mortality [men RR=1.57 (95% CI 1.46–1.68); women RR=2.0 (95% CI 1.89–2.12)], RR=1.76 (95% CI 1.66–1.88) for cardiovascular mortality and RR=2.26 (95% CI: 1.7-3.02) for stroke. There was no statistically significant evidence of publication bias. Conclusion: Type 2 diabetes increases mortality approximately two-fold increase and macrovascular disease is the principal cause of death. |