• Comparing Terahertz transmission response on pH-dependent apomyoglobin proteins dynamics with circular dichroism

      Qiu, Junyi; Yang, Bin; Sushko, Oleksandr; Pikersgill, Richard W.; Donnan, Robert S.; University of Chester (IEEE, 2014-12-08)
      Terahertz time domain spectroscopy (THz-TDS) was used to study the transmission responses of pH-dependent apomyoglobin (ApoMb) dissolved solutions in 0.2-2.2 THz frequency domain, the THz-TDS technique was also benchmarked against circular dichroism (CD) by studying pH-related folding states changes of ApoMb protein. Results revealed that differences of pH-dependent ApoMb/water dynamics can be detected directly by the THz refractive index spectrum, and these differences are further proved to be caused mainly the effect of protonation of water and possibly water response leaded by protein conformation change.
    • The power of VNA-driven quasi-optics to sense group molecular action in condensed phase systems

      Donnan, Robert S.; Tian, Kun V.; Yang, Bin; Chass, Gregory A.; University of Chester (2014-12-08)
      The versatility for quasi-optical circuits, driven by modern vector network analysers, is demonstrated for the purpose of low energy (meV) coherent spectroscopy. One such example is shown applied to the curing dynamics of a non-mercury-based dental cement. This highlights the special place the methodology holds as a `soft-probe' to reveal the time-resolved energetics of condensed phased systems as they self-organise to adopt their low energy state.