Homocysteine and cognitive decline in healthy elderly

Authors
McCaddon, Andrew
Hudson, Peter R.
Davies, Gareth K.
Hughes, Alan
Williams, John H. H.
Wilkinson, Clare
Affiliation
University of Wales College of Medicine ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Royal Alexandra Hospital, Paisley ; Chester College ; University of Wales College of Medicine
Publication Date
2001-09

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Abstract
Serum homocysteine is increased, and correlates inversely with cognitive scores, in Alzheimer's disease (AD), vascular dementia and "age-associated memory impairment". Elevated levels might signal accelerated cognitive decline, although this remains to be established. We therefore repeated Mini-Mental State Examinations, together with additional ADAS-Cog assessments, in 32 healthy elderly individuals to determine whether prior homocysteine levels predicted cognitive changes over a 5-year period.
Citation
Dementia and Geriatric Cognitive Disorders, 2001, 12(5), pp. 309-313
Publisher
Karger
Journal
Dementia and Geriatric Cognitive Disorders
URI
http://hdl.handle.net/10034/226331
DOI
10.1159/000051275
Additional Links
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=224226
Type
Article
Language
en
Description
This article is not available through ChesterRep.
ISSN
1421-9824
1420-8008
Sponsors
This article was submitted to the RAE2008 for the University of Chester - Allied Health Professions and Studies.
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