• Login / Register
    View Item 
    •   Home
    • Faculty of Medicine, Dentistry and Life Sciences
    • Biological Sciences
    • Biological Sciences
    • View Item
    •   Home
    • Faculty of Medicine, Dentistry and Life Sciences
    • Biological Sciences
    • Biological Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChesterRepCommunitiesTitleAuthorsPublication DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsPublication DateSubmit DateSubjectsPublisherJournalProfilesView

    My Account

    LoginRegister

    About

    AboutUniversity of Chester

    Statistics

    Display statistics

    Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    McCarthy, Helen S.
    Williams, John H. H.
    Davie, Michael W. J.
    Marshall, Michael J.
    Affiliation
    Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry / University of Chester ; University of Chester ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry
    Publication Date
    2008-11-20
    
    Metadata
    Show full item record
    Abstract
    This article discusses how osteoprotegerin (OPG) production by osteoblastic cells was stimulated by platelet-derived growth factor (PDGF) in two human osteosarcoma cell lines (MG63, Saos-2), a mouse pre-osteoblastic cell line (MC3T3-E1) and human bone marrow stromal cells (hMSC) by 152%, 197%, 113% and 45% respectively over 24 h. OPG was measured in the cell culture medium by immunoassay. PDGF isoforms AA, BB and AB show similar stimulation of OPG production. Message for OPG was also increased similarly to the increased secretion into the culture medium. Using specific inhibitors of cell signalling the authors demonstrate that PDGF acts through the PDGF receptor, PKC, PI3K, ERK and P38 and not via NF-kB or JNK. The importance of PDGF in fracture healing suggests a role for OPG production in countering bone resorption during the early phase of this process.
    Citation
    Journal of Cellular Physiology, 218(2), 2009, pp. 350-354
    Publisher
    Wiley
    Journal
    Journal of Cellular Physiology
    URI
    http://hdl.handle.net/10034/208689
    DOI
    10.1002/jcp.21600
    Additional Links
    http://doi.wiley.com/10.1002/jcp.21600
    Type
    Article
    Language
    en
    Description
    This article is not available through ChesterRep.
    ISSN
    0021-9541
    1097-4652
    Sponsors
    The Bone Disease Foundation
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcp.21600
    Scopus Count
    Collections
    Biological Sciences

    entitlement

     
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.