Increased circulating Dickkopf-1 in Paget's disease of bone
| dc.contributor.author | Marshall, Michael J. | * |
| dc.contributor.author | Evans, Sally F. | * |
| dc.contributor.author | Sharp, Christopher A. | * |
| dc.contributor.author | Powell, Diane E. | * |
| dc.contributor.author | McCarthy, Helen S. | * |
| dc.contributor.author | Davie, Michael W. J. | * |
| dc.date.accessioned | 2011-12-16T17:11:49Z | |
| dc.date.available | 2011-12-16T17:11:49Z | |
| dc.date.issued | 2009-07 | |
| dc.identifier.citation | Clinical Biochemistry, 42(10-11), 2009, pp. 965-969 | |
| dc.identifier.issn | 0009-9120 | en |
| dc.identifier.uri | http://hdl.handle.net/10034/197720 | |
| dc.description | This article is not available through ChesterRep. | |
| dc.description.abstract | This article discusses Dickkopf-1 (Dkk-1), which is a secreted inhibitor of Wnt signaling which in adults regulates bone turnover. Dkk-1 over-production is implicated in osteolytic disease where it inhibits bone formation and stimulates bone breakdown. Recently it was reported that osteoblastic cells from Paget's disease of bone (PDB) over-expressed Dkk-1. This study aimed yo see if increased Dkk-1 was detected in serum from patients with PDB. The results showed that Dkk-1 and total serum alkaline phosphatase activity (tsAP) were significantly elevated in sera from PDB patients. Patients with polyostotic PDB had significantly higher levels of tsAP but not Dkk-1, than monostotic patients. TsAP but not Dkk-1, was significantly lower in sera from bisphosphonate treated versus untreated PDB patients. Dkk-1 and tsAP were not significantly correlated. Dkk-1 may be a useful biomarker of PDB and the authors speculate that Dkk-1 may play a central role in the etiology of PDB. | |
| dc.language.iso | en | en |
| dc.publisher | Elsevier | |
| dc.relation.url | http://www.journals.elsevier.com/clinical-biochemistry/ | en |
| dc.subject | dickkopf-1 | en |
| dc.subject | serum | en |
| dc.subject | Paget's disease of bone | en |
| dc.subject | Alkaline phosphatase | en |
| dc.subject | wnt | en |
| dc.subject | inhibitor | en |
| dc.title | Increased circulating Dickkopf-1 in Paget's disease of bone | en |
| dc.type | Article | |
| dc.contributor.department | Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry / University of Chester ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry | |
| dc.identifier.journal | Clinical Biochemistry | en |
| dc.date.accepted | 2009-04-07 | |
| html.description.abstract | This article discusses Dickkopf-1 (Dkk-1), which is a secreted inhibitor of Wnt signaling which in adults regulates bone turnover. Dkk-1 over-production is implicated in osteolytic disease where it inhibits bone formation and stimulates bone breakdown. Recently it was reported that osteoblastic cells from Paget's disease of bone (PDB) over-expressed Dkk-1. This study aimed yo see if increased Dkk-1 was detected in serum from patients with PDB. The results showed that Dkk-1 and total serum alkaline phosphatase activity (tsAP) were significantly elevated in sera from PDB patients. Patients with polyostotic PDB had significantly higher levels of tsAP but not Dkk-1, than monostotic patients. TsAP but not Dkk-1, was significantly lower in sera from bisphosphonate treated versus untreated PDB patients. Dkk-1 and tsAP were not significantly correlated. Dkk-1 may be a useful biomarker of PDB and the authors speculate that Dkk-1 may play a central role in the etiology of PDB. |