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Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems
Hazell, Gavin Arnold, Thomas Tognoloni, Cecilia Barker, Robert Clifton, Luke Steinke, Nina-Juliane Edler, Karen
Hazell, Gavin
Arnold, Thomas
Tognoloni, Cecilia
Barker, Robert
Clifton, Luke
Steinke, Nina-Juliane
Edler, Karen
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2016-10-14
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Nanodisc.pdf
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Abstract
Styrene-alt-maleic Acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “nanodiscs” and lipid monolayers adsorbed at either solid-liquid or air-liquid interfaces. This behavior has important implications for the potential uses of nanodiscs, including the potential to control lipid composition within nanodiscs containing membrane proteins
Citation
Hazell, G., Arnold, T., Barker, R., Clifton, L., Steinke, N., Tognoloni, C., & Edler, K. (2016). Evidence of lipid exchange in styrene maleic acid lipid particle (SMALP) nanodisc systems. Langmuir, 32(45), 11845-11853
Publisher
American Chemical Society
Journal
Langmuir
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Article
Language
en
Description
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.langmuir.6b02927
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ISSN
0743-7463
EISSN
1520-5827