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Entropy-driven cell decision-making predicts "fluid-to-solid" transition in multicellular systems
Kavallaris, Nikos Barua, Arnab Syga, Simon Mascheroni, Pietro Meyer-Hermann, Michael Deutsch, Andreas Hatzikirou, Haralampos
Kavallaris, Nikos
Barua, Arnab
Syga, Simon
Mascheroni, Pietro
Meyer-Hermann, Michael
Deutsch, Andreas
Hatzikirou, Haralampos
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2020-12-22
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Abstract
Cellular decision making allows cells to assume functionally different phenotypes in response to microenvironmental cues, with or without genetic change. It is an open question, how individual cell decisions influence the dynamics at the tissue level. Here, we study spatio-temporal pattern formation in a population of cells exhibiting phenotypic plasticity, which is a paradigm of cell decision making. We focus on the migration/resting and the migration/proliferation plasticity which underly the epithelial-mesenchymal transition (EMT) and the go or grow dichotomy. We assume that cells change their phenotype in order to minimize their microenvironmental entropy following the LEUP (Least microEnvironmental Uncertainty Principle) hypothesis. In turn, we study the impact of the LEUP-driven migration/resting and migration/proliferation plasticity on the corresponding multicellular spatiotemporal dynamics with a stochastic cell-based mathematical model for the spatio-temporal dynamics of the cell phenotypes. In the case of the go or rest plasticity, a corresponding mean-field approximation allows to identify a bistable switching mechanism between a diffusive (fluid) and an epithelial (solid) tissue phase which depends on the sensitivity of the phenotypes to the environment. For the go or grow plasticity, we show the possibility of Turing pattern formation for the "solid" tissue phase and its relation with the parameters of the LEUP-driven cell decisions.
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Barua, A., Syga, S., Mascheroni, P., Kavallaris, N., Meyer-Hermann, M., Deutsch, A., & Hatzikirou, H. (2020). Entropy-driven cell-decision making predicts fluid-to-solid transition in multicellular systems. New Journal of Physics, 22, 123034. https://doi.org/10.1088/1367-2630/abcb2e
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IOP Publishing
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New Journal of Physics
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This is an author-created, un-copyedited version of an article accepted for publication in the New Journal of Physics. The publisher is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1367-2630/abcb2e.
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1367-2630