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Model-directed engineering of “difficult-to-express” monoclonal antibody production by Chinese hamster ovary cells

Pybus, Leon P.
; 
Dean, Greg
; 
West, Nathan R.
; 
Smith, Andrew
; 
Daramola, Olalekan
; 
Field, Ray
; 
Wilkinson, Stephen J.
; 
James, David C.
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Affiliation
University of Sheffield ; BioPharmaceutical Development ; University of Sheffield ; BioPharmaceutical Development ; BioPharmaceutical Development ; BioPharmaceutical Development ; University of Sheffield ; University of Sheffield
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Publication Date
2013-11-14
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Chemical Engineering
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Abstract
Despite improvements in volumetric titer for monoclonal antibody (MAb) production processes using Chinese hamster ovary (CHO) cells, some “difficult-to-express” (DTE) MAbs inexplicably reach much lower process titers.
Citation
Model-directed engineering of “difficult-to-express” monoclonal antibody production by Chinese hamster ovary cells. Biotechnology and Bioengineering, 2014, 111(2), pp. 372-385
Publisher
Wiley
Journal
Biotechnology and Bioengineering
Research Unit
URI
http://hdl.handle.net/10034/552294
DOI
10.1002/bit.25116
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PubMed Central ID
Type
Article
Language
en
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ISSN
0006-3592
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http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0290
 http://doi.wiley.com/10.1002/bit.25116
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