Regional differences in mechanical and material properties of femoral head cancellous bone in health and osteoarthritis

Hdl Handle:
http://hdl.handle.net/10034/71215
Title:
Regional differences in mechanical and material properties of femoral head cancellous bone in health and osteoarthritis
Authors:
Brown, Sharon J.; Pollintine, Phillip; Powell, Diane E.; Davie, Michael W. J.; Sharp, Christopher A.
Abstract:
Osteoarthritis (OA) is a debilitating condition common among the aging population. In this study we have determined mechanical and material properties of cancellous bone cores from two differently loaded regions of femoral heads obtained from healthy subjects and those with end-stage osteoarthritis. Densitometric properties were determined prior to compression testing for Young's modulus (EC) and yield strength (sy), after which bones were powdered for analysis of collagen and mineral content. In both OA and normal cancellous bone, volumetric bone mineral density (BMDv), apparent density (rA), EC, and sy were systematically greater in the superior than in the inferior region (P<0.05). In the OA inferior region, median BMDv (0.434 g-cm-3) and rA (0.426 g-cm-3) were significantly greater than in normals (0.329 and 0.287 g-cm-3, respectively, both P<0.05) reflecting an increased amount of tissue. The mineral:collagen ratio was decreased in OA, but this was only significant in the superior region (P<0.008). Relationships between EC and both BMDv and rA were weaker in OA bone cores (r2 = 0.66 and r2 = 0.59) than in normals (r2 = 0.86 and r2 = 0.77, respectively). Likewise, sy and both BMDv and rA were weaker in OA (r2 = 0.74 and r2 = 0.70) than in normals (r2 = 0.83 and r2 = 0.77, respectively). For the same value of density measure, EC and sy tended to be lower in OA bone when compared with normal bone. In conclusion, femoral head cancellous bone mass in end-stage osteoarthritis is increased but undermineralized, and is neither stiffer nor stronger than normal cancellous bone.
Affiliation:
Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry/Chester College of Higher Education ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry
Citation:
Calcified Tissue International, 2004, 71(3), pp. 277-234
Publisher:
Springer
Journal:
Calcified Tissue International
Publication Date:
2002
URI:
http://hdl.handle.net/10034/71215
DOI:
10.1007/s00223-001-2102-y
Additional Links:
http://www.springerlink.com/content/100120/?p=cfe63ef1040042f39635a3eb031d6bcd&p_o=85
Type:
Article
Language:
en
Description:
This article is not available through ChesterRep.
ISSN:
0171-967X; 1432-0827
Appears in Collections:
Biological Sciences

Full metadata record

DC FieldValue Language
dc.contributor.authorBrown, Sharon J.en
dc.contributor.authorPollintine, Phillipen
dc.contributor.authorPowell, Diane E.en
dc.contributor.authorDavie, Michael W. J.en
dc.contributor.authorSharp, Christopher A.en
dc.date.accessioned2009-06-23T08:59:33Zen
dc.date.available2009-06-23T08:59:33Zen
dc.date.issued2002en
dc.identifier.citationCalcified Tissue International, 2004, 71(3), pp. 277-234en
dc.identifier.issn0171-967Xen
dc.identifier.issn1432-0827en
dc.identifier.doi10.1007/s00223-001-2102-yen
dc.identifier.urihttp://hdl.handle.net/10034/71215en
dc.descriptionThis article is not available through ChesterRep.en
dc.description.abstractOsteoarthritis (OA) is a debilitating condition common among the aging population. In this study we have determined mechanical and material properties of cancellous bone cores from two differently loaded regions of femoral heads obtained from healthy subjects and those with end-stage osteoarthritis. Densitometric properties were determined prior to compression testing for Young's modulus (EC) and yield strength (sy), after which bones were powdered for analysis of collagen and mineral content. In both OA and normal cancellous bone, volumetric bone mineral density (BMDv), apparent density (rA), EC, and sy were systematically greater in the superior than in the inferior region (P<0.05). In the OA inferior region, median BMDv (0.434 g-cm-3) and rA (0.426 g-cm-3) were significantly greater than in normals (0.329 and 0.287 g-cm-3, respectively, both P<0.05) reflecting an increased amount of tissue. The mineral:collagen ratio was decreased in OA, but this was only significant in the superior region (P<0.008). Relationships between EC and both BMDv and rA were weaker in OA bone cores (r2 = 0.66 and r2 = 0.59) than in normals (r2 = 0.86 and r2 = 0.77, respectively). Likewise, sy and both BMDv and rA were weaker in OA (r2 = 0.74 and r2 = 0.70) than in normals (r2 = 0.83 and r2 = 0.77, respectively). For the same value of density measure, EC and sy tended to be lower in OA bone when compared with normal bone. In conclusion, femoral head cancellous bone mass in end-stage osteoarthritis is increased but undermineralized, and is neither stiffer nor stronger than normal cancellous bone.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://www.springerlink.com/content/100120/?p=cfe63ef1040042f39635a3eb031d6bcd&p_o=85en
dc.subjectosteoarthritisen
dc.subjectcompressive modulusen
dc.subjectcancellous boneen
dc.subjectfemoral headen
dc.subjectbone densityen
dc.titleRegional differences in mechanical and material properties of femoral head cancellous bone in health and osteoarthritisen
dc.typeArticleen
dc.contributor.departmentCharles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry/Chester College of Higher Education ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestryen
dc.identifier.journalCalcified Tissue Internationalen
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