Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease
Authors
McCaddon, AndrewBleenow, Kaj
Hudson, Peter R.
Hughes, Alan
Barber, Joan
Gray, Rob
Davies, Gareth K.
Williams, John H. H.
Duguid, Jennifer
Lloyd, Alwyn
Tandy, Steve
Everall, Marge
Cattell, Howard
McCaddon, Anne
Ellis, Dick
Palmer, Mona
Bogdanovic, Nenad
Gottfires, Carl-Gerhard
Zetterberg, Henrik
Rymo, Lars
Regland, Björn
Affiliation
University of Wales College of Medicine; University of Goteborg; Wrexham Maelor Hospital; Royal Alexandra Hospital; Garnock Day Hospital/Ayrshire Central Hospital; University College Chester; University Hospital of Wales; Huddinge University HospitalPublication Date
2004-03-17
Metadata
Show full item recordAbstract
Isoforms of the vitamin B<12< carrier protein transcobalamin (TC) might influence its cellular availability and contribute to the association between disrupted single-carbon metabolism and Alzheimer's disease (AD). We therefore investigated the relationships between the TC 776C>G (Pro259Arg) genetic polymorphism, total serum cobalamin and holo-TC levels, and disease onset in 70 patients with clinically diagnosed AD and 74 healthy elderly controls. TC 776C>G polymorphism was also determined for 94 histopathologically confirmed AD patients and 107 controls. Serum holo-TC levels were significantly higher in TC 776C homozygotes (p = 0.04). Kaplan-Meier survival functions differed between homozygous genotypes (Cox's F-Test F(42, 46) = 2.1; p = 0.008) and between 776C homozygotes and heterozygotes (Cox's F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study.Citation
McCaddon, A., Bleenow, K., Hudson, P. R., Hughes, A., Barber, J., Gray, R., Davies, G. K., Williams, J. H. H., Duguid, J., Lloyd, A., Tandy, S., Everall, M., Cattell, H., McCaddon, A., Ellis, D., Palmer, M., Bogdanovic, N., Gottfires, C-G., Zetterberg, H., ... Regland, B. (2004). Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 17(3), 215-221. https://doi.org/10.1159/000076359Publisher
Karger PublishersAdditional Links
http://www.karger.comType
ArticleLanguage
enDescription
This article is not available through ChesterRep.ISSN
1420-8008Sponsors
This article was submitted to the RAE2008 for the University of Chester - Allied Health Professions and Studies.ae974a485f413a2113503eed53cd6c53
10.1159/000076359