Hdl Handle:
http://hdl.handle.net/10034/620530
Title:
First Pass Metabolism
Authors:
Robertson, Deborah A. F.
Abstract:
In this article in the series of ‘bite sized’ pharmacology, we will look at the concept of first pass metabolism. All drugs given by the oral route undergo a degree of first pass metabolism either in the gut or the liver, with some drugs being destroyed before they reach the systemic circulation. This pharmacokinetic process affects the bioavailability of drugs administered by this route and is an important consideration for the prescriber. Knowledge of first pass metabolism can assist the prescriber when deciding on doses and dose schedules to ensure that patients receive their medications at the correct dosing, by the correct route for optimum therapeutic effect. It also helps the prescriber understand why dose adjustments are made for some drugs when switching the route of administration from oral and why some drugs cannot be given by the oral route.
Affiliation:
University of Chester
Citation:
Robertson, D. (2017). First Pass Metabolism Nurse Prescribing, 15(6).
Publisher:
Mark Allen Healthcare Ltd
Journal:
Nurse Prescribing
Publication Date:
Jun-2017
URI:
http://hdl.handle.net/10034/620530
Additional Links:
http://www.markallengroup.com/ma-healthcare/nurse-prescribing
Type:
Article
Language:
en
ISSN:
1479-9189
Appears in Collections:
Health and Social Care

Full metadata record

DC FieldValue Language
dc.contributor.authorRobertson, Deborah A. F.en
dc.date.accessioned2017-06-08T12:50:55Z-
dc.date.available2017-06-08T12:50:55Z-
dc.date.issued2017-06-
dc.identifier.citationRobertson, D. (2017). First Pass Metabolism Nurse Prescribing, 15(6).en
dc.identifier.issn1479-9189-
dc.identifier.urihttp://hdl.handle.net/10034/620530-
dc.description.abstractIn this article in the series of ‘bite sized’ pharmacology, we will look at the concept of first pass metabolism. All drugs given by the oral route undergo a degree of first pass metabolism either in the gut or the liver, with some drugs being destroyed before they reach the systemic circulation. This pharmacokinetic process affects the bioavailability of drugs administered by this route and is an important consideration for the prescriber. Knowledge of first pass metabolism can assist the prescriber when deciding on doses and dose schedules to ensure that patients receive their medications at the correct dosing, by the correct route for optimum therapeutic effect. It also helps the prescriber understand why dose adjustments are made for some drugs when switching the route of administration from oral and why some drugs cannot be given by the oral route.en
dc.language.isoenen
dc.publisherMark Allen Healthcare Ltden
dc.relation.urlhttp://www.markallengroup.com/ma-healthcare/nurse-prescribingen
dc.subjectPrescribingen
dc.subjectPharmacologyen
dc.titleFirst Pass Metabolismen
dc.typeArticleen
dc.contributor.departmentUniversity of Chesteren
dc.identifier.journalNurse Prescribingen
dc.date.accepted2017-05-16-
or.grant.openaccessYesen
rioxxterms.funderUnfundeden
rioxxterms.identifier.projectUnfundeden
rioxxterms.versionAMen
rioxxterms.licenseref.startdate2017-06-08-
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