Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review.

Hdl Handle:
http://hdl.handle.net/10034/620435
Title:
Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review.
Authors:
Agbalalah, Tari; Hughes, Stephen F.; Freeborn, Ellen J.; Mushtaq, Sohail
Abstract:
This systematic review aims to evaluate randomised controlled trials (RCTs) investigating the effect of vitamin D supplementation on endothelial function and inflammation in adults. An electronic search of published randomised controlled trials, using Cochrane, Pubmed and Medline databases was conducted, with the search terms related to vitamin D and endothelial function. Inclusion criteria were RCTs in adult humans with a measure of vitamin D status using serum/plasma 25(OH)D and studies which administered the intervention through the oral route. Among the 1107 studies retrieved, 29 studies met the full inclusion criteria for this systematic review. Overall, 8 studies reported significant improvements in the endothelial/inflammatory biomarkers/parameters measured. However, in 2 out of the 8 studies, improvements were reported at interim time points, but improvements were absent post-intervention. The remaining 21 trial studies did not show significant improvements in the markers of interest measured. Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults, results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters. This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect.
Affiliation:
University of Chester
Citation:
Agbalalah, T., Hughes, S. F., Freeborn, E. J., & Mushtaq, S. (2017). Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review. Journal of Steroid Biochemistry and Molecular Biology. http://dx.doi.org/10.1016/j.jsbmb.2017.01.015.
Publisher:
Elsevier
Journal:
Journal of Steroid Biochemistry and Molecular Biology
Publication Date:
23-Jan-2017
URI:
http://hdl.handle.net/10034/620435
DOI:
10.1016/j.jsbmb.2017.01.015
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0960076017300158
Type:
Article
Language:
en
EISSN:
1879-1220
Appears in Collections:
Clinical Sciences and Nutrition

Full metadata record

DC FieldValue Language
dc.contributor.authorAgbalalah, Tarien
dc.contributor.authorHughes, Stephen F.en
dc.contributor.authorFreeborn, Ellen J.en
dc.contributor.authorMushtaq, Sohailen
dc.date.accessioned2017-03-14T10:12:20Z-
dc.date.available2017-03-14T10:12:20Z-
dc.date.issued2017-01-23-
dc.identifier.citationAgbalalah, T., Hughes, S. F., Freeborn, E. J., & Mushtaq, S. (2017). Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review. Journal of Steroid Biochemistry and Molecular Biology. http://dx.doi.org/10.1016/j.jsbmb.2017.01.015.en
dc.identifier.doi10.1016/j.jsbmb.2017.01.015-
dc.identifier.urihttp://hdl.handle.net/10034/620435-
dc.description.abstractThis systematic review aims to evaluate randomised controlled trials (RCTs) investigating the effect of vitamin D supplementation on endothelial function and inflammation in adults. An electronic search of published randomised controlled trials, using Cochrane, Pubmed and Medline databases was conducted, with the search terms related to vitamin D and endothelial function. Inclusion criteria were RCTs in adult humans with a measure of vitamin D status using serum/plasma 25(OH)D and studies which administered the intervention through the oral route. Among the 1107 studies retrieved, 29 studies met the full inclusion criteria for this systematic review. Overall, 8 studies reported significant improvements in the endothelial/inflammatory biomarkers/parameters measured. However, in 2 out of the 8 studies, improvements were reported at interim time points, but improvements were absent post-intervention. The remaining 21 trial studies did not show significant improvements in the markers of interest measured. Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults, results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters. This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0960076017300158en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectVitamin Den
dc.subject25(OH)Den
dc.subjectEndothelial functionen
dc.subjectInflammationen
dc.subjectFlow mediated dilationen
dc.subjectRandomised controlled trialsen
dc.titleImpact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review.en
dc.typeArticleen
dc.identifier.eissn1879-1220-
dc.contributor.departmentUniversity of Chesteren
dc.identifier.journalJournal of Steroid Biochemistry and Molecular Biologyen
dc.date.accepted2017-01-22-
or.grant.openaccessYesen
rioxxterms.funderUnfundeden
rioxxterms.identifier.projectUnfundeden
rioxxterms.versionAMen
rioxxterms.licenseref.startdate2018-01-23-
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