Hdl Handle:
http://hdl.handle.net/10034/620421
Title:
Modelling the molecular mechanisms of ageing
Authors:
Mc Auley, Mark T.; Martinez Guimera, Alvaro; Hodgson, David; McDonald, Neil; Mooney, Kathleen M.; Morgan, Amy; Proctor, Carole
Abstract:
The ageing process is driven at the cellular level by random molecular damage which slowly accumulates with age. Although cells possess mechanisms to repair or remove damage, they are not 100% efficient and their efficiency declines with age. There are many molecular mechanisms involved and exogenous factors such as stress also contribute to the ageing process. The complexity of the ageing process has stimulated the use of computational modelling in order to increase our understanding of the system, test hypotheses and make testable predictions. As many different mechanisms are involved, a wide range of models have been developed. This paper gives an overview of the types of models that have been developed, the range of tools used, modelling standards, and discusses many specific examples of models which have been grouped according to the main mechanisms that they address. We conclude by discussing the opportunities and challenges for future modelling in this field.
Affiliation:
University of Chester; Edgehill University; Newcastle University
Citation:
Mc Auley, M. T., et. al.(2017). Modelling the molecular mechanisms of ageing. Bioscience reports, 37(1). DOI: 10.1042/BSR20160177
Publisher:
Portland Press
Journal:
Bioscience reports
Publication Date:
23-Feb-2017
URI:
http://hdl.handle.net/10034/620421
DOI:
10.1042/BSR20160177
Additional Links:
http://www.bioscirep.org/content/37/1/BSR20160177
Type:
Article
Language:
en
Description:
This document is the Accepted Manuscript version of a published work that appeared in final form in Bioscience reports. To access the final edited and published work see http://www.bioscirep.org/content/37/1/BSR20160177.
EISSN:
1573-4935
Appears in Collections:
Chemical Engineering

Full metadata record

DC FieldValue Language
dc.contributor.authorMc Auley, Mark T.en
dc.contributor.authorMartinez Guimera, Alvaroen
dc.contributor.authorHodgson, Daviden
dc.contributor.authorMcDonald, Neilen
dc.contributor.authorMooney, Kathleen M.en
dc.contributor.authorMorgan, Amyen
dc.contributor.authorProctor, Caroleen
dc.date.accessioned2017-02-28T16:26:26Z-
dc.date.available2017-02-28T16:26:26Z-
dc.date.issued2017-02-23-
dc.identifier.citationMc Auley, M. T., et. al.(2017). Modelling the molecular mechanisms of ageing. Bioscience reports, 37(1). DOI: 10.1042/BSR20160177en
dc.identifier.doi10.1042/BSR20160177-
dc.identifier.urihttp://hdl.handle.net/10034/620421-
dc.descriptionThis document is the Accepted Manuscript version of a published work that appeared in final form in Bioscience reports. To access the final edited and published work see http://www.bioscirep.org/content/37/1/BSR20160177.en
dc.description.abstractThe ageing process is driven at the cellular level by random molecular damage which slowly accumulates with age. Although cells possess mechanisms to repair or remove damage, they are not 100% efficient and their efficiency declines with age. There are many molecular mechanisms involved and exogenous factors such as stress also contribute to the ageing process. The complexity of the ageing process has stimulated the use of computational modelling in order to increase our understanding of the system, test hypotheses and make testable predictions. As many different mechanisms are involved, a wide range of models have been developed. This paper gives an overview of the types of models that have been developed, the range of tools used, modelling standards, and discusses many specific examples of models which have been grouped according to the main mechanisms that they address. We conclude by discussing the opportunities and challenges for future modelling in this field.en
dc.language.isoenen
dc.publisherPortland Pressen
dc.relation.urlhttp://www.bioscirep.org/content/37/1/BSR20160177en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMathematical modelingen
dc.subjectAgeingen
dc.titleModelling the molecular mechanisms of ageingen
dc.typeArticleen
dc.identifier.eissn1573-4935-
dc.contributor.departmentUniversity of Chester; Edgehill University; Newcastle Universityen
dc.identifier.journalBioscience reportsen
dc.date.accepted2017-01-16-
or.grant.openaccessYesen
rioxxterms.funderUnfundeden
rioxxterms.identifier.projectUnfundeden
rioxxterms.versionAMen
rioxxterms.licenseref.startdate2017-02-23-
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