Obesity and the Dysregulation of Fatty Acid Metabolism: Implications for Healthy Aging

Hdl Handle:
http://hdl.handle.net/10034/620190
Title:
Obesity and the Dysregulation of Fatty Acid Metabolism: Implications for Healthy Aging
Authors:
Morgan, Amy; Mooney, Kathleen M.; Mc Auley, Mark T.
Abstract:
The population of the world is aging. In 2010, an estimated 524 million people were aged 65 years or older presenting eight percent of the global population. By 2050, this number is expected to nearly triple to approximately 1.5 billion, 16 percent of the world’s population. Although people are living longer, the quality of their lives are often compromised due to ill-health. Areas covered. Of the conditions which compromise health as we age, obesity is at the forefront. Over half of the global older population were overweight or obese in 2010, significantly increasing the risk of a range of metabolic diseases. Although, it is well recognised excessive calorie intake is a fundamental driver of adipose tissue dysfunction, the relationship between obesity; intrinsic aging; and fat metabolism is less understood. In this review we discuss the intersection between obesity, aging and the factors which contribute to the dysregulation of whole-body fat metabolism. Expert Commentary. Being obese disrupts an array of physiological systems and there is significant crosstalk among these. Moreover it is imperative to acknowledge the contribution intrinsic aging makes to the dysregulation of these systems and the onset of disease.
Affiliation:
University of Chester; Edge Hill University
Citation:
Morgan, A., Mooney, K., Mc Auley, M. T. (2016). Obesity and the Dysregulation of Fatty Acid Metabolism: Implications for Healthy Aging. Expert Review of Endocrinology & Metabolism, 11(6), 501-510. DOI: 10.1080/17446651.2016.1245141
Publisher:
Taylor & Francis
Journal:
Expert Review of Endocrinology & Metabolism
Publication Date:
17-Oct-2016
URI:
http://hdl.handle.net/10034/620190
DOI:
10.1080/17446651.2016.1245141
Additional Links:
http://www.tandfonline.com/toc/iere20/current
Type:
Article
Language:
en
Description:
This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Endocrinology & Metabolism on 17/10/2016, available online: http://dx.doi.org/10.1080/17446651.2016.1245141
EISSN:
1744-8417
Appears in Collections:
Chemical Engineering

Full metadata record

DC FieldValue Language
dc.contributor.authorMorgan, Amyen
dc.contributor.authorMooney, Kathleen M.en
dc.contributor.authorMc Auley, Mark T.en
dc.date.accessioned2016-10-03T09:15:30Z-
dc.date.available2016-10-03T09:15:30Z-
dc.date.issued2016-10-17-
dc.identifier.citationMorgan, A., Mooney, K., Mc Auley, M. T. (2016). Obesity and the Dysregulation of Fatty Acid Metabolism: Implications for Healthy Aging. Expert Review of Endocrinology & Metabolism, 11(6), 501-510. DOI: 10.1080/17446651.2016.1245141en
dc.identifier.doi10.1080/17446651.2016.1245141-
dc.identifier.urihttp://hdl.handle.net/10034/620190-
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Endocrinology & Metabolism on 17/10/2016, available online: http://dx.doi.org/10.1080/17446651.2016.1245141-
dc.description.abstractThe population of the world is aging. In 2010, an estimated 524 million people were aged 65 years or older presenting eight percent of the global population. By 2050, this number is expected to nearly triple to approximately 1.5 billion, 16 percent of the world’s population. Although people are living longer, the quality of their lives are often compromised due to ill-health. Areas covered. Of the conditions which compromise health as we age, obesity is at the forefront. Over half of the global older population were overweight or obese in 2010, significantly increasing the risk of a range of metabolic diseases. Although, it is well recognised excessive calorie intake is a fundamental driver of adipose tissue dysfunction, the relationship between obesity; intrinsic aging; and fat metabolism is less understood. In this review we discuss the intersection between obesity, aging and the factors which contribute to the dysregulation of whole-body fat metabolism. Expert Commentary. Being obese disrupts an array of physiological systems and there is significant crosstalk among these. Moreover it is imperative to acknowledge the contribution intrinsic aging makes to the dysregulation of these systems and the onset of disease.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://www.tandfonline.com/toc/iere20/currenten
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAgeingen
dc.subjectFatty acid metabolismen
dc.titleObesity and the Dysregulation of Fatty Acid Metabolism: Implications for Healthy Agingen
dc.typeArticleen
dc.identifier.eissn1744-8417-
dc.contributor.departmentUniversity of Chester; Edge Hill Universityen
dc.identifier.journalExpert Review of Endocrinology & Metabolismen
dc.date.accepted2016-09-27-
or.grant.openaccessYesen
rioxxterms.funderUnfundeden
rioxxterms.identifier.projectUnfundeden
rioxxterms.versionAMen
rioxxterms.licenseref.startdate2216-10-03-
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