Factors Associated with Intentional and Unintentional Non-adherence to Adjuvant Endocrine Therapy Following Breast Cancer

Hdl Handle:
http://hdl.handle.net/10034/620179
Title:
Factors Associated with Intentional and Unintentional Non-adherence to Adjuvant Endocrine Therapy Following Breast Cancer
Authors:
Brett, Jo; Fenlon, Deborah F.; Boulton, Mary; Hulbert-Williams, Nicholas J.; Walter, Fiona; Donnelly, Peter; Lavery, Bernadette; Morgan, Adrienne; Morris, Carolyn; Watson, Eila
Abstract:
Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be sub-optimal despite its known efficacy in reducing recurrence and mortality. This study aims to investigate factors associated with non-adherence and inform the development of interventions to support women and promote adherence. A questionnaire survey to measure level of adherence, side effects experienced, beliefs about medicine, support received and socio-demographic details was sent to 292 women 2-4 years post breast cancer diagnosis. Differences between non-adherers and adherers to AET were explored, and factors associated with intentional and unintentional non-adherence are reported. Approximately one quarter of respondents, 46 (22%), were non-adherers, comprising 29 (14%) intentional non-adherers and 17 (8%) unintentional non-adherers. Factors significantly associated with intentional non-adherence were: the presence of side effects (p<0.03), greater concerns about AET (p<0.001), and a lower perceived necessity to take AET (p<0.001). Half of the sample (105/211) reported that side effects had a moderate or high impact on their quality of life. Factors associated with unintentional non-adherence were: younger age (<65), (p<0.001), post-secondary education (p=0.046), and paid employment (p=0.031). There are distinct differences between intentional non-adherence and unintentional non-adherence. Differentiation between the two types of non-adherence may help tailor support and advice interventions
Affiliation:
University of Chester
Citation:
Brett, J., et. al. (2016). Factors Associated with Intentional and Unintentional Non-adherence to Adjuvant Endocrine Therapy Following Breast Cancer. DOI: 10.1111/ecc.12601
Publisher:
Wiley
Journal:
European Journal of Cancer Care
Publication Date:
30-Nov-2016
URI:
http://hdl.handle.net/10034/620179
DOI:
10.1111/ecc.12601
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1111/ecc.12601/abstract
Type:
Article
Language:
en
Description:
This is the peer reviewed version of the following article: Brett, J., et. al. (2016). Factors Associated with Intentional and Unintentional Non-adherence to Adjuvant Endocrine Therapy Following Breast Cancer. DOI: 10.1111/ecc.12601, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/ecc.12601/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
EISSN:
1365-2354
Appears in Collections:
Psychology

Full metadata record

DC FieldValue Language
dc.contributor.authorBrett, Joen
dc.contributor.authorFenlon, Deborah F.en
dc.contributor.authorBoulton, Maryen
dc.contributor.authorHulbert-Williams, Nicholas J.en
dc.contributor.authorWalter, Fionaen
dc.contributor.authorDonnelly, Peteren
dc.contributor.authorLavery, Bernadetteen
dc.contributor.authorMorgan, Adrienneen
dc.contributor.authorMorris, Carolynen
dc.contributor.authorWatson, Eilaen
dc.date.accessioned2016-09-27T12:54:20Z-
dc.date.available2016-09-27T12:54:20Z-
dc.date.issued2016-11-30-
dc.identifier.citationBrett, J., et. al. (2016). Factors Associated with Intentional and Unintentional Non-adherence to Adjuvant Endocrine Therapy Following Breast Cancer. DOI: 10.1111/ecc.12601en
dc.identifier.doi10.1111/ecc.12601-
dc.identifier.urihttp://hdl.handle.net/10034/620179-
dc.descriptionThis is the peer reviewed version of the following article: Brett, J., et. al. (2016). Factors Associated with Intentional and Unintentional Non-adherence to Adjuvant Endocrine Therapy Following Breast Cancer. DOI: 10.1111/ecc.12601, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/ecc.12601/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving-
dc.description.abstractAdherence to adjuvant endocrine therapy (AET) following breast cancer is known to be sub-optimal despite its known efficacy in reducing recurrence and mortality. This study aims to investigate factors associated with non-adherence and inform the development of interventions to support women and promote adherence. A questionnaire survey to measure level of adherence, side effects experienced, beliefs about medicine, support received and socio-demographic details was sent to 292 women 2-4 years post breast cancer diagnosis. Differences between non-adherers and adherers to AET were explored, and factors associated with intentional and unintentional non-adherence are reported. Approximately one quarter of respondents, 46 (22%), were non-adherers, comprising 29 (14%) intentional non-adherers and 17 (8%) unintentional non-adherers. Factors significantly associated with intentional non-adherence were: the presence of side effects (p<0.03), greater concerns about AET (p<0.001), and a lower perceived necessity to take AET (p<0.001). Half of the sample (105/211) reported that side effects had a moderate or high impact on their quality of life. Factors associated with unintentional non-adherence were: younger age (<65), (p<0.001), post-secondary education (p=0.046), and paid employment (p=0.031). There are distinct differences between intentional non-adherence and unintentional non-adherence. Differentiation between the two types of non-adherence may help tailor support and advice interventionsen
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1111/ecc.12601/abstracten
dc.subjectAdjuvant Endocrine Therapyen
dc.subjectBreast Canceren
dc.subjectNon-adherenceen
dc.subjectIntentional non-adherenceen
dc.subjectBMQen
dc.subjectSide effectsen
dc.titleFactors Associated with Intentional and Unintentional Non-adherence to Adjuvant Endocrine Therapy Following Breast Canceren
dc.typeArticleen
dc.identifier.eissn1365-2354-
dc.contributor.departmentUniversity of Chesteren
dc.identifier.journalEuropean Journal of Cancer Careen
dc.date.accepted2016-09-14-
or.grant.openaccessYesen
rioxxterms.funderUnfundeden
rioxxterms.identifier.projectUnfundeden
rioxxterms.versionAMen
rioxxterms.licenseref.startdate2216-09-27-
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