Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation

Hdl Handle:
http://hdl.handle.net/10034/617858
Title:
Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation
Authors:
Morgan, Amy; Mooney, Kathleen M.; Wilkinson, Stephen J.; Pickles, Neil; Mc Auley, Mark T.
Abstract:
Cholesterol plays a vital role in the human body as a precursor of steroid hormones and bile acids, in addition to providing structure to cell membranes. Whole body cholesterol metabolism is maintained by a highly coordinated balancing act between cholesterol ingestion, synthesis, absorption, and excretion. The aim of this review is to discuss how ageing interacts with these processes. Firstly, we will present an overview of cholesterol metabolism. Following this, we discuss how the biological mechanisms which underpin cholesterol metabolism are effected by ageing. Included in this discussion are lipoprotein dynamics, cholesterol absorption/synthesis and the enterohepatic circulation/synthesis of bile acids. Moreover, we discuss the role of oxidative stress in the pathological progression of atherosclerosis and also discuss how cholesterol biosynthesis is effected by both the mammalian target of rapamycin and sirtuin pathways. Next, we examine how diet and alterations to the gut microbiome can be used to mitigate the impact ageing has on cholesterol metabolism. We conclude by discussing how mathematical models of cholesterol metabolism can be used to identify therapeutic interventions.
Affiliation:
University of Chester, Edgehill University
Citation:
Morgan, A. E., Mooney, K. M., Wilkinson, S. J., Pickles, N. A., & Mc Auley, M. T. (2016). Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation. Ageing Research Reviews, 27, 108-124. doi: http://dx.doi.org/10.1016/j.arr.2016.03.008
Publisher:
Elsevier
Journal:
Ageing Research Reviews
Publication Date:
1-Apr-2016
URI:
http://hdl.handle.net/10034/617858
DOI:
10.1016/j.arr.2016.03.008
Additional Links:
http://www.sciencedirect.com/science/article/pii/S1568163716300332
Type:
Article
Language:
en
ISSN:
1568-1637
Appears in Collections:
Chemical Engineering

Full metadata record

DC FieldValue Language
dc.contributor.authorMorgan, Amyen
dc.contributor.authorMooney, Kathleen M.en
dc.contributor.authorWilkinson, Stephen J.en
dc.contributor.authorPickles, Neilen
dc.contributor.authorMc Auley, Mark T.en
dc.date.accessioned2016-08-02T18:07:45Z-
dc.date.available2016-08-02T18:07:45Z-
dc.date.issued2016-04-01-
dc.identifier.citationMorgan, A. E., Mooney, K. M., Wilkinson, S. J., Pickles, N. A., & Mc Auley, M. T. (2016). Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation. Ageing Research Reviews, 27, 108-124. doi: http://dx.doi.org/10.1016/j.arr.2016.03.008en
dc.identifier.issn1568-1637-
dc.identifier.doi10.1016/j.arr.2016.03.008-
dc.identifier.urihttp://hdl.handle.net/10034/617858-
dc.description.abstractCholesterol plays a vital role in the human body as a precursor of steroid hormones and bile acids, in addition to providing structure to cell membranes. Whole body cholesterol metabolism is maintained by a highly coordinated balancing act between cholesterol ingestion, synthesis, absorption, and excretion. The aim of this review is to discuss how ageing interacts with these processes. Firstly, we will present an overview of cholesterol metabolism. Following this, we discuss how the biological mechanisms which underpin cholesterol metabolism are effected by ageing. Included in this discussion are lipoprotein dynamics, cholesterol absorption/synthesis and the enterohepatic circulation/synthesis of bile acids. Moreover, we discuss the role of oxidative stress in the pathological progression of atherosclerosis and also discuss how cholesterol biosynthesis is effected by both the mammalian target of rapamycin and sirtuin pathways. Next, we examine how diet and alterations to the gut microbiome can be used to mitigate the impact ageing has on cholesterol metabolism. We conclude by discussing how mathematical models of cholesterol metabolism can be used to identify therapeutic interventions.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S1568163716300332en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAgeingen
dc.subjectCholesterol metabolismen
dc.titleCholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulationen
dc.typeArticleen
dc.contributor.departmentUniversity of Chester, Edgehill Universityen
dc.identifier.journalAgeing Research Reviewsen
dc.date.accepted2016-03-30-
or.grant.openaccessYesen
rioxxterms.funderinternalen
rioxxterms.identifier.projectinternalen
rioxxterms.versionPen
rioxxterms.licenseref.startdate2017-06-01-
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