Hdl Handle:
http://hdl.handle.net/10034/606590
Title:
Regulation and roles of Ca2+ stores in human sperm.
Authors:
Correia, Joao; Michelangeli, Francesco; Publicover, Stephen
Abstract:
[Ca(2)(+)]i signalling is a key regulatory mechanism in sperm function. In mammalian sperm the Ca(2)(+)-permeable plasma membrane ion channel CatSper is central to [Ca(2)(+)]i signalling, but there is good evidence that Ca(2)(+) stored in intracellular organelles is also functionally important. Here we briefly review the current understanding of the diversity of Ca(2)(+) stores and the mechanisms for the regulation of their activity. We then consider the evidence for the involvement of these stores in [Ca(2)(+)]i signalling in mammalian (primarily human) sperm, the agonists that may activate these stores and their role in control of sperm function. Finally we consider the evidence that membrane Ca(2)(+) channels and stored Ca(2)(+) may play discrete roles in the regulation of sperm activities and propose a mechanism by which these different components of the sperm Ca(2)(+)-signalling apparatus may interact to generate complex and spatially diverse [Ca(2)(+)]i signals.
Affiliation:
University of Birmingham
Citation:
Correia, J., Michelangeli, F., & Publicover, S. (2015). Regulation and roles of Ca2+ stores in human sperm. Reproduction, 150(2), R65-R76. doi:10.1530/rep-15-0102
Publisher:
Bioscientifica
Journal:
Reproduction
Publication Date:
11-May-2015
URI:
http://hdl.handle.net/10034/606590
DOI:
doi: 10.1530/REP-15-0102
Additional Links:
http://www.reproduction-online.org/content/150/2/R65.abstract?sid=a6190f59-e443-493f-91be-a5993e1690dc
Type:
Article
Language:
en
ISSN:
1470-1626
Sponsors:
Wellcome Trust
Appears in Collections:
Biological Sciences

Full metadata record

DC FieldValue Language
dc.contributor.authorCorreia, Joaoen
dc.contributor.authorMichelangeli, Francescoen
dc.contributor.authorPublicover, Stephenen
dc.date.accessioned2016-04-22T13:24:48Zen
dc.date.available2016-04-22T13:24:48Zen
dc.date.issued2015-05-11en
dc.identifier.citationCorreia, J., Michelangeli, F., & Publicover, S. (2015). Regulation and roles of Ca2+ stores in human sperm. Reproduction, 150(2), R65-R76. doi:10.1530/rep-15-0102en
dc.identifier.issn1470-1626en
dc.identifier.doidoi: 10.1530/REP-15-0102en
dc.identifier.urihttp://hdl.handle.net/10034/606590en
dc.description.abstract[Ca(2)(+)]i signalling is a key regulatory mechanism in sperm function. In mammalian sperm the Ca(2)(+)-permeable plasma membrane ion channel CatSper is central to [Ca(2)(+)]i signalling, but there is good evidence that Ca(2)(+) stored in intracellular organelles is also functionally important. Here we briefly review the current understanding of the diversity of Ca(2)(+) stores and the mechanisms for the regulation of their activity. We then consider the evidence for the involvement of these stores in [Ca(2)(+)]i signalling in mammalian (primarily human) sperm, the agonists that may activate these stores and their role in control of sperm function. Finally we consider the evidence that membrane Ca(2)(+) channels and stored Ca(2)(+) may play discrete roles in the regulation of sperm activities and propose a mechanism by which these different components of the sperm Ca(2)(+)-signalling apparatus may interact to generate complex and spatially diverse [Ca(2)(+)]i signals.en
dc.description.sponsorshipWellcome Trusten
dc.language.isoenen
dc.publisherBioscientificaen
dc.relation.urlhttp://www.reproduction-online.org/content/150/2/R65.abstract?sid=a6190f59-e443-493f-91be-a5993e1690dcen
dc.rightsAn error occurred on the license name.*
dc.rights.uriAn error occurred getting the license - uri.en
dc.subjectReproductionen
dc.subjectCell biologyen
dc.titleRegulation and roles of Ca2+ stores in human sperm.en
dc.typeArticleen
dc.contributor.departmentUniversity of Birminghamen
dc.identifier.journalReproductionen
dc.date.accepted2015-05-11en
or.grant.openaccessYesen
rioxxterms.funderunfundeden
rioxxterms.identifier.projectunfunded researchen
rioxxterms.versionAOen
rioxxterms.licenseref.startdate2016-05-11en
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