Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA

Hdl Handle:
http://hdl.handle.net/10034/604379
Title:
Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA
Authors:
Pickard, Mark R.; Williams, Gwyn T.
Abstract:
It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biology may therefore offer new insights into pathogenetic mechanisms and thereby offer novel opportunities for diagnosis and therapy. Of particular interest in this regard is GAS5 lncRNA, which is down-regulated in multiple cancers, with expression levels related to both clinico-pathological characteristics and patient prognosis. Functional studies have further shown that GAS5 lncRNA both inhibits the proliferation and promotes the apoptosis of multiple cell types, and that together these cellular mechanisms of action are likely to form the basis of its tumour suppressor action. At the same time, advances have been made in our understanding of the molecular mechanisms of GAS5 lncRNA action in recent years, including riborepression of certain steroid hormone receptors and sequestration of miR-21, impacting key regulatory pathways of cell survival. Overall this accumulating knowledge has the potential to improve both the diagnosis and treatment of cancer, and ultimately patient outcome.
Affiliation:
Keele University
Citation:
Pickard, M. R. & Williams, G. T. (2015). Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA. Genes, 6(3), 484-99. DOI: 10.3390/genes6030484
Publisher:
MDPI
Journal:
Genes
Publication Date:
7-Jul-2015
URI:
http://hdl.handle.net/10034/604379
DOI:
10.3390/genes6030484
PubMed ID:
26198250
Additional Links:
http://www.mdpi.com/2073-4425/6/3/484; http://www.ncbi.nlm.nih.gov/pubmed/?term=26198250
Type:
Article
Language:
en
EISSN:
2073-4425
Sponsors:
Breast Cancer Campaign, Prostate Cancer United Kingdom
Appears in Collections:
Institute of Medicine

Full metadata record

DC FieldValue Language
dc.contributor.authorPickard, Mark R.en
dc.contributor.authorWilliams, Gwyn T.en
dc.date.accessioned2016-04-04T13:39:47Zen
dc.date.available2016-04-04T13:39:47Zen
dc.date.issued2015-07-07en
dc.identifier.citationPickard, M. R. & Williams, G. T. (2015). Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA. Genes, 6(3), 484-99. DOI: 10.3390/genes6030484en
dc.identifier.pmid26198250en
dc.identifier.doi10.3390/genes6030484en
dc.identifier.urihttp://hdl.handle.net/10034/604379en
dc.description.abstractIt is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biology may therefore offer new insights into pathogenetic mechanisms and thereby offer novel opportunities for diagnosis and therapy. Of particular interest in this regard is GAS5 lncRNA, which is down-regulated in multiple cancers, with expression levels related to both clinico-pathological characteristics and patient prognosis. Functional studies have further shown that GAS5 lncRNA both inhibits the proliferation and promotes the apoptosis of multiple cell types, and that together these cellular mechanisms of action are likely to form the basis of its tumour suppressor action. At the same time, advances have been made in our understanding of the molecular mechanisms of GAS5 lncRNA action in recent years, including riborepression of certain steroid hormone receptors and sequestration of miR-21, impacting key regulatory pathways of cell survival. Overall this accumulating knowledge has the potential to improve both the diagnosis and treatment of cancer, and ultimately patient outcome.en
dc.description.sponsorshipBreast Cancer Campaign, Prostate Cancer United Kingdomen
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urlhttp://www.mdpi.com/2073-4425/6/3/484en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/?term=26198250en
dc.subjectGAS5en
dc.subjectApoptosisen
dc.subjectCanceren
dc.subjectCell proliferationen
dc.subjectlncRNAen
dc.subjectTumour suppressoren
dc.titleMolecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNAen
dc.typeArticleen
dc.identifier.eissn2073-4425en
dc.contributor.departmentKeele Universityen
dc.identifier.journalGenesen

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