Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence

Hdl Handle:
http://hdl.handle.net/10034/604068
Title:
Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence
Authors:
Bannister, Jim R.; Khan, Abdul L.; Eccleston, David W.; Deol-Poonia, Ranjeev K.; Hughes, Stephen F.
Abstract:
Introduction. This pilot study evaluated the expression of the proinflammatory cytokine IL-17 along the Barrett’s metaplasia-dysplasia-adenocarcinoma sequence by establishing the expression levels of IL-17 in columnar epithelium, intestinal metaplastic cells, and dysplastic/glandular neoplastic cells. Immunohistochemical techniques were used to examine the accumulation of the proinflammatory cytokine IL-17 in forty () formalin-fixed, paraffin-embedded oesophageal archived specimens across a range of endoscopic diagnostic categories, and a highly significant difference was found, where , in IL-17 expression (Kruskall Wallis and Mann-Whitney ) between all the cell types examined. There was also a strong positive correlation (Spearman's rank correlation) between disease progression and IL-17 expression (, , ), IL-17 expression was absent or absent/weak in columnar epithelium, weak to moderate in columnar metaplastic cells, and moderate to strong in dysplastic/neoplastic cells, which demonstrated that the elevation of IL-17 expression occurs in the progression of the disease. Understanding the differential expression of IL-17 between benign and malignant tissue potentially has a significant diagnostic, prognostic, and therapeutic value. Ultimately, this selective biomarker may be employed in routine clinical practice for the screening of oesophageal adenocarcinoma.
Affiliation:
University of Chester; Aintree University Hospital
Citation:
Bannister, J. R., Khan, A. L., Eccleston, D. W., Deol-Poonia, R. K., & Hughes, S. F. (2012). Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence. International Scholarly Research Network Inflammation, 2012, Article ID 578149, 6 pages. DOI:10.5402/2012/578149
Publisher:
Hindawi Publishing Corporation
Journal:
ISRN Inflammation
Publication Date:
30-Dec-2012
URI:
http://hdl.handle.net/10034/604068
DOI:
10.5402/2012/578149
Additional Links:
http://www.hindawi.com/journals/isrn/2012/578149/cta/; http://europepmc.org/articles/PMC3765756
Type:
Article
Language:
en
Description:
Original Research Article
EISSN:
2090-8695
Sponsors:
The authors thankfully acknowledge the University of Chester for their financial support.
Appears in Collections:
Biological Sciences

Full metadata record

DC FieldValue Language
dc.contributor.authorBannister, Jim R.en
dc.contributor.authorKhan, Abdul L.en
dc.contributor.authorEccleston, David W.en
dc.contributor.authorDeol-Poonia, Ranjeev K.en
dc.contributor.authorHughes, Stephen F.en
dc.date.accessioned2016-03-31T14:36:31Zen
dc.date.available2016-03-31T14:36:31Zen
dc.date.issued2012-12-30en
dc.identifier.citationBannister, J. R., Khan, A. L., Eccleston, D. W., Deol-Poonia, R. K., & Hughes, S. F. (2012). Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence. International Scholarly Research Network Inflammation, 2012, Article ID 578149, 6 pages. DOI:10.5402/2012/578149en
dc.identifier.doi10.5402/2012/578149en
dc.identifier.urihttp://hdl.handle.net/10034/604068en
dc.descriptionOriginal Research Articleen
dc.description.abstractIntroduction. This pilot study evaluated the expression of the proinflammatory cytokine IL-17 along the Barrett’s metaplasia-dysplasia-adenocarcinoma sequence by establishing the expression levels of IL-17 in columnar epithelium, intestinal metaplastic cells, and dysplastic/glandular neoplastic cells. Immunohistochemical techniques were used to examine the accumulation of the proinflammatory cytokine IL-17 in forty () formalin-fixed, paraffin-embedded oesophageal archived specimens across a range of endoscopic diagnostic categories, and a highly significant difference was found, where , in IL-17 expression (Kruskall Wallis and Mann-Whitney ) between all the cell types examined. There was also a strong positive correlation (Spearman's rank correlation) between disease progression and IL-17 expression (, , ), IL-17 expression was absent or absent/weak in columnar epithelium, weak to moderate in columnar metaplastic cells, and moderate to strong in dysplastic/neoplastic cells, which demonstrated that the elevation of IL-17 expression occurs in the progression of the disease. Understanding the differential expression of IL-17 between benign and malignant tissue potentially has a significant diagnostic, prognostic, and therapeutic value. Ultimately, this selective biomarker may be employed in routine clinical practice for the screening of oesophageal adenocarcinoma.en
dc.description.sponsorshipThe authors thankfully acknowledge the University of Chester for their financial support.en
dc.language.isoenen
dc.publisherHindawi Publishing Corporationen
dc.relation.urlhttp://www.hindawi.com/journals/isrn/2012/578149/cta/en
dc.relation.urlhttp://europepmc.org/articles/PMC3765756en
dc.subjectCanceren
dc.subjectbiomarkeren
dc.titleInterleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequenceen
dc.typeArticleen
dc.identifier.eissn2090-8695en
dc.contributor.departmentUniversity of Chester; Aintree University Hospitalen
dc.identifier.journalISRN Inflammationen
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