Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

Hdl Handle:
http://hdl.handle.net/10034/596355
Title:
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
Authors:
Eccles, Suzanne A.; Aboagye, Eric O.; Ali, Simak; Anderson, Annie S.; Armes, Jo; Berditchevski, Fedor; Blaydes, Jeremy P.; Brennan, Keith; Brown, Nicola J.; Bryant, Helen E.; Bundred, Nigel J.; Burchell, Joy M.; Campbell, Anna M.; Carroll, Jason S.; Clarke, Robert B.; Coles, Charlotte E.; Cook, Gary J.; Cox, Angela; Curtin, Nicola J.; Dekker, Lodewijk V.; dos Santos Silva, Isabel; Duffy, Stephen W.; Easton, Douglas F.; Eccles, Diana M.; Edwards, Dylan R.; Edwards, Joanne; Evans, D. Gareth; Fenlon, Deborah F.; Flanagan, James M.; Foster, Claire; Gallagher, William M.; Garcia-Closas, Montserrat; Gee, Julia M. W.; Gescher, Andy J.; Goh, Vicky; Groves, Ashley M.; Harvey, Amanda J.; Harvie, Michelle N.; Hennessy, Bryan T.; Hiscox, Stephen; Holen, Ingunn; Howell, Sacha J.; Howell, Anthony; Hubbard, Gill; Hulbert-Williams, Nicholas J.; Hunter, Myra S.; Jasani, Bharat; Jones, Louise J.; Key, Timothy J.; Kirwan, Cliona C.; Kong, Anthony; Kunkler, Ian H.; Langdon, Simon P.; Leach, Martin O.; Mann, David J.; Marshall, John F.; Martin, Lesley A.; Martin, Stewart G.; Macdougall, Jennifer E.; Miles, David W.; Miller, William R.; Morris, Joanna R.; Moss, Sue M.; Mullan, Paul; Natrajan, Rachel; O’Connor, James P.; O’Connor, Rosemary; Palmieri, Carlo; Pharoah, Paul D. P.; Rakha, Emad A.; Reed, Elizabeth; Robinson, Simon P.; Sahai, Erik; Saxton, John M.; Schmid, Peter; Smalley, Matthew J.; Speirs, Valerie; Stein, Robert; Stingl, John; Streuli, Charles H.; Tutt, Andrew N. J.; Velikova, Galina; Walker, Rosemary A.; Watson, Christine J.; Williams, Kaye J.; Young, Leonie S.; Thompson, Alastair M.
Abstract:
Introduction: Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.
Affiliation:
Imperial College London ; University of Dundee ; University of Southampton ; University of Birmingham ; University of Manchester ; University of Sheffield ; Kings College London ; University College London ; Cancer Research UK/University of Cambridge ; Newcastle University ; University of Nottingham ; London School of Hygiene and Tropical Medicine ; Queen Mary University of London ; University of Glasgow ; University of East Anglia ; University College Dublin ; The Institute of Cancer Research ; University of Cardiff ; University of Leeds ; Royal College of Surgeons Ireland ; University of Chester ; University of Oxford ; University of Edinburgh ; National Cancer Research Institute ; Queen’s University Belfast ; University College Cork ; University of Leicester ; Princess Alice Hospice ; University of Sussex ; University of Liverpool ; London Research Institute ; Brunel University ; Cambridge University Hospitals NHS
Citation:
Eccles, et. al. (2013). Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research, 15(5), R92.
Publisher:
BioMed Central
Journal:
Breast Cancer Research
Publication Date:
1-Oct-2013
URI:
http://hdl.handle.net/10034/596355
DOI:
10.1186/bcr3493
Additional Links:
http://link.springer.com/article/10.1186%2Fbcr3493; http://www.ncbi.nlm.nih.gov/pubmed/24286369
Type:
Article
Language:
en
Description:
Gold OA
EISSN:
1465-542X
Appears in Collections:
Gold OA; Psychology

Full metadata record

DC FieldValue Language
dc.contributor.authorEccles, Suzanne A.en
dc.contributor.authorAboagye, Eric O.en
dc.contributor.authorAli, Simaken
dc.contributor.authorAnderson, Annie S.en
dc.contributor.authorArmes, Joen
dc.contributor.authorBerditchevski, Fedoren
dc.contributor.authorBlaydes, Jeremy P.en
dc.contributor.authorBrennan, Keithen
dc.contributor.authorBrown, Nicola J.en
dc.contributor.authorBryant, Helen E.en
dc.contributor.authorBundred, Nigel J.en
dc.contributor.authorBurchell, Joy M.en
dc.contributor.authorCampbell, Anna M.en
dc.contributor.authorCarroll, Jason S.en
dc.contributor.authorClarke, Robert B.en
dc.contributor.authorColes, Charlotte E.en
dc.contributor.authorCook, Gary J.en
dc.contributor.authorCox, Angelaen
dc.contributor.authorCurtin, Nicola J.en
dc.contributor.authorDekker, Lodewijk V.en
dc.contributor.authordos Santos Silva, Isabelen
dc.contributor.authorDuffy, Stephen W.en
dc.contributor.authorEaston, Douglas F.en
dc.contributor.authorEccles, Diana M.en
dc.contributor.authorEdwards, Dylan R.en
dc.contributor.authorEdwards, Joanneen
dc.contributor.authorEvans, D. Garethen
dc.contributor.authorFenlon, Deborah F.en
dc.contributor.authorFlanagan, James M.en
dc.contributor.authorFoster, Claireen
dc.contributor.authorGallagher, William M.en
dc.contributor.authorGarcia-Closas, Montserraten
dc.contributor.authorGee, Julia M. W.en
dc.contributor.authorGescher, Andy J.en
dc.contributor.authorGoh, Vickyen
dc.contributor.authorGroves, Ashley M.en
dc.contributor.authorHarvey, Amanda J.en
dc.contributor.authorHarvie, Michelle N.en
dc.contributor.authorHennessy, Bryan T.en
dc.contributor.authorHiscox, Stephenen
dc.contributor.authorHolen, Ingunnen
dc.contributor.authorHowell, Sacha J.en
dc.contributor.authorHowell, Anthonyen
dc.contributor.authorHubbard, Gillen
dc.contributor.authorHulbert-Williams, Nicholas J.en
dc.contributor.authorHunter, Myra S.en
dc.contributor.authorJasani, Bharaten
dc.contributor.authorJones, Louise J.en
dc.contributor.authorKey, Timothy J.en
dc.contributor.authorKirwan, Cliona C.en
dc.contributor.authorKong, Anthonyen
dc.contributor.authorKunkler, Ian H.en
dc.contributor.authorLangdon, Simon P.en
dc.contributor.authorLeach, Martin O.en
dc.contributor.authorMann, David J.en
dc.contributor.authorMarshall, John F.en
dc.contributor.authorMartin, Lesley A.en
dc.contributor.authorMartin, Stewart G.en
dc.contributor.authorMacdougall, Jennifer E.en
dc.contributor.authorMiles, David W.en
dc.contributor.authorMiller, William R.en
dc.contributor.authorMorris, Joanna R.en
dc.contributor.authorMoss, Sue M.en
dc.contributor.authorMullan, Paulen
dc.contributor.authorNatrajan, Rachelen
dc.contributor.authorO’Connor, James P.en
dc.contributor.authorO’Connor, Rosemaryen
dc.contributor.authorPalmieri, Carloen
dc.contributor.authorPharoah, Paul D. P.en
dc.contributor.authorRakha, Emad A.en
dc.contributor.authorReed, Elizabethen
dc.contributor.authorRobinson, Simon P.en
dc.contributor.authorSahai, Eriken
dc.contributor.authorSaxton, John M.en
dc.contributor.authorSchmid, Peteren
dc.contributor.authorSmalley, Matthew J.en
dc.contributor.authorSpeirs, Valerieen
dc.contributor.authorStein, Roberten
dc.contributor.authorStingl, Johnen
dc.contributor.authorStreuli, Charles H.en
dc.contributor.authorTutt, Andrew N. J.en
dc.contributor.authorVelikova, Galinaen
dc.contributor.authorWalker, Rosemary A.en
dc.contributor.authorWatson, Christine J.en
dc.contributor.authorWilliams, Kaye J.en
dc.contributor.authorYoung, Leonie S.en
dc.contributor.authorThompson, Alastair M.en
dc.date.accessioned2016-02-16T12:18:44Zen
dc.date.available2016-02-16T12:18:44Zen
dc.date.issued2013-10-01en
dc.identifier.citationEccles, et. al. (2013). Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research, 15(5), R92.en
dc.identifier.doi10.1186/bcr3493en
dc.identifier.urihttp://hdl.handle.net/10034/596355en
dc.descriptionGold OAen
dc.description.abstractIntroduction: Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://link.springer.com/article/10.1186%2Fbcr3493en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24286369en
dc.subjectBreast canceren
dc.titleCritical research gaps and translational priorities for the successful prevention and treatment of breast canceren
dc.typeArticleen
dc.identifier.eissn1465-542Xen
dc.contributor.departmentImperial College London ; University of Dundee ; University of Southampton ; University of Birmingham ; University of Manchester ; University of Sheffield ; Kings College London ; University College London ; Cancer Research UK/University of Cambridge ; Newcastle University ; University of Nottingham ; London School of Hygiene and Tropical Medicine ; Queen Mary University of London ; University of Glasgow ; University of East Anglia ; University College Dublin ; The Institute of Cancer Research ; University of Cardiff ; University of Leeds ; Royal College of Surgeons Ireland ; University of Chester ; University of Oxford ; University of Edinburgh ; National Cancer Research Institute ; Queen’s University Belfast ; University College Cork ; University of Leicester ; Princess Alice Hospice ; University of Sussex ; University of Liverpool ; London Research Institute ; Brunel University ; Cambridge University Hospitals NHSen
dc.identifier.journalBreast Cancer Researchen
dc.language.rfc3066enen
dc.rights.holderEccles et al.; licensee BioMed Central Ltd.en
dc.date.updated2015-09-16T19:36:02Zen
This item is licensed under a Creative Commons License
Creative Commons
All Items in ChesterRep are protected by copyright, with all rights reserved, unless otherwise indicated.