Exploration of basal diurnal salivary cortisol profiles in middle-aged adults: Associations with sleep quality and metabolic parameters

Hdl Handle:
http://hdl.handle.net/10034/558303
Title:
Exploration of basal diurnal salivary cortisol profiles in middle-aged adults: Associations with sleep quality and metabolic parameters
Authors:
Lasikiewicz, Nicola; Hendrickx, Hilde; Talbot, Duncan; Dye, Louise
Abstract:
The use of saliva samples is a practical and feasible method to explore basal diurnal cortisol profiles in free-living research. This study explores a number of psychological and physiological characteristics in relation to the observed pattern of salivary cortisol activity over a 12-h period with particular emphasis on sleep. Basal diurnal cortisol profiles were examined in a sample of 147 volunteers (mean age 46.2177.18 years). Profiles were constructed for each volunteer and explored in terms of the area under the curve (AUC) of the cortisol-awakening response with samples obtained immediately upon waking (0, 15, 30 and 45 min post waking) and at 3, 6, 9 and 12 h post waking to assess diurnal decline. Diurnal mean of cortisol was based on the mean of cortisol at time points 3, 6, 9 and 12 h post waking. Psychological measures of perceived stress and sleep were collected with concurrent biological assessment of fasting plasma glucose, insulin, blood lipids and inflammatory markers. Blunted cortisol profiles, characterised by a reduced AUC, were observed in the majority (78%) of a middle-aged sample and were associated with significantly poorer sleep quality and significantly greater waist-hip ratio (WHR). Blunted cortisol profiles were further associated with a tendency to exhibit a less favourable metabolic profile. These findings suggest that reduced cortisol secretion post waking may serve as an additional marker of psychological and biological vulnerability to adverse health outcomes in middle-aged adults.
Citation:
Psychoneuroendocrinology (2007), 33(2), 143-151
Publisher:
Elsevier
Journal:
Psychoneuroendocrinology
Publication Date:
27-Sep-2007
URI:
http://hdl.handle.net/10034/558303
Type:
Article
Language:
en
ISSN:
0306-4530
Appears in Collections:
Psychology

Full metadata record

DC FieldValue Language
dc.contributor.authorLasikiewicz, Nicolaen
dc.contributor.authorHendrickx, Hildeen
dc.contributor.authorTalbot, Duncanen
dc.contributor.authorDye, Louiseen
dc.date.accessioned2015-06-22T10:51:21Zen
dc.date.available2015-06-22T10:51:21Zen
dc.date.issued2007-09-27en
dc.identifier.citationPsychoneuroendocrinology (2007), 33(2), 143-151en
dc.identifier.issn0306-4530en
dc.identifier.urihttp://hdl.handle.net/10034/558303en
dc.description.abstractThe use of saliva samples is a practical and feasible method to explore basal diurnal cortisol profiles in free-living research. This study explores a number of psychological and physiological characteristics in relation to the observed pattern of salivary cortisol activity over a 12-h period with particular emphasis on sleep. Basal diurnal cortisol profiles were examined in a sample of 147 volunteers (mean age 46.2177.18 years). Profiles were constructed for each volunteer and explored in terms of the area under the curve (AUC) of the cortisol-awakening response with samples obtained immediately upon waking (0, 15, 30 and 45 min post waking) and at 3, 6, 9 and 12 h post waking to assess diurnal decline. Diurnal mean of cortisol was based on the mean of cortisol at time points 3, 6, 9 and 12 h post waking. Psychological measures of perceived stress and sleep were collected with concurrent biological assessment of fasting plasma glucose, insulin, blood lipids and inflammatory markers. Blunted cortisol profiles, characterised by a reduced AUC, were observed in the majority (78%) of a middle-aged sample and were associated with significantly poorer sleep quality and significantly greater waist-hip ratio (WHR). Blunted cortisol profiles were further associated with a tendency to exhibit a less favourable metabolic profile. These findings suggest that reduced cortisol secretion post waking may serve as an additional marker of psychological and biological vulnerability to adverse health outcomes in middle-aged adults.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectcortisolen
dc.subjecthumansen
dc.subjectstressen
dc.subjectsleepen
dc.subjectobesityen
dc.subjectdiurnal profileen
dc.titleExploration of basal diurnal salivary cortisol profiles in middle-aged adults: Associations with sleep quality and metabolic parametersen
dc.typeArticleen
dc.identifier.journalPsychoneuroendocrinologyen
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