Hdl Handle:
http://hdl.handle.net/10034/347044
Title:
Prenatal exposures and exposomics of asthma
Authors:
Choi, Hyunok; Mc Auley, Mark T.; Lawrence, David A.
Abstract:
This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental media
Affiliation:
University at Albany ; University of Chester ; Center for Medical Sciences, Albany, NY
Citation:
AIMS Environmental Science, 2015, 2(1), pp. 87-109.
Publisher:
AIMS Press
Journal:
AIMS Environmental Science
Publication Date:
19-Feb-2015
URI:
http://hdl.handle.net/10034/347044
DOI:
10.3934/environsci.2015.1.87
Additional Links:
http://www.aimspress.com/aimses/ch/reader/view_abstract.aspx?file_no=Environ2014015&flag=1
Type:
Article
Language:
en_US
Appears in Collections:
Chemical Engineering

Full metadata record

DC FieldValue Language
dc.contributor.authorChoi, Hyunoken
dc.contributor.authorMc Auley, Mark T.en
dc.contributor.authorLawrence, David A.en
dc.date.accessioned2015-03-24T11:21:06Zen
dc.date.available2015-03-24T11:21:06Zen
dc.date.issued2015-02-19en
dc.identifier.citationAIMS Environmental Science, 2015, 2(1), pp. 87-109.en
dc.identifier.doi10.3934/environsci.2015.1.87en
dc.identifier.urihttp://hdl.handle.net/10034/347044en
dc.description.abstractThis review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental mediaen
dc.language.isoen_USen
dc.publisherAIMS Pressen
dc.relation.urlhttp://www.aimspress.com/aimses/ch/reader/view_abstract.aspx?file_no=Environ2014015&flag=1en
dc.subjectasthmaen
dc.subjectmathematical modellingen
dc.titlePrenatal exposures and exposomics of asthmaen_US
dc.typeArticleen
dc.contributor.departmentUniversity at Albany ; University of Chester ; Center for Medical Sciences, Albany, NYen
dc.identifier.journalAIMS Environmental Scienceen
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