Computationally modeling lipid metabolism and aging: A mini-review

Hdl Handle:
http://hdl.handle.net/10034/344379
Title:
Computationally modeling lipid metabolism and aging: A mini-review
Authors:
Mc Auley, Mark T.; Mooney, Kathleen M.
Abstract:
One of the greatest challenges in biology is to improve the understanding of the mechanisms which underpin aging and how these affect health. The need to better understand aging is amplified by demographic changes, which have caused a gradual increase in the global population of older people. Aging western populations have resulted in a rise in the prevalence of age-related pathologies. Of these diseases, cardiovascular disease is the most common underlying condition in older people. The dysregulation of lipid metabolism due to aging impinges significantly on cardiovascular health. However, the multifaceted nature of lipid metabolism and the complexities of its interaction with aging make it challenging to understand by conventional means. To address this challenge computational modeling, a key component of the systems biology paradigm is being used to study the dynamics of lipid metabolism. This mini-review briefly outlines the key regulators of lipid metabolism, their dysregulation, and how computational modeling is being used to gain an increased insight into this system.
Affiliation:
University of Chester ; Edge Hill University
Citation:
Computational and Structural Biotechnology Journal, 2015, 13, pp. 38-46. Available online 15 November 2014
Publisher:
Elsevier
Journal:
Computational and Structural Biotechnology Journal
Publication Date:
15-Nov-2014
URI:
http://hdl.handle.net/10034/344379
DOI:
10.1016/j.csbj.2014.11.006
Additional Links:
www.elsevier.com/locate/csbj; http://linkinghub.elsevier.com/retrieve/pii/S2001037014000476
Type:
Article
Language:
en
Description:
This is an Version of Record of an article published in Computational and Structural Biotechnology Journal in 15 November 2014, available online: http://dx.doi.org/10.1016/j.csbj.2014.11.006 This is an open-access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/ licenses/by/3.0/
ISSN:
2001-0370
Appears in Collections:
Chemical Engineering

Full metadata record

DC FieldValue Language
dc.contributor.authorMc Auley, Mark T.en
dc.contributor.authorMooney, Kathleen M.en
dc.date.accessioned2015-02-11T17:35:30Zen
dc.date.available2015-02-11T17:35:30Zen
dc.date.issued2014-11-15en
dc.identifier.citationComputational and Structural Biotechnology Journal, 2015, 13, pp. 38-46. Available online 15 November 2014en
dc.identifier.issn2001-0370en
dc.identifier.doi10.1016/j.csbj.2014.11.006en
dc.identifier.urihttp://hdl.handle.net/10034/344379en
dc.descriptionThis is an Version of Record of an article published in Computational and Structural Biotechnology Journal in 15 November 2014, available online: http://dx.doi.org/10.1016/j.csbj.2014.11.006 This is an open-access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/ licenses/by/3.0/en
dc.description.abstractOne of the greatest challenges in biology is to improve the understanding of the mechanisms which underpin aging and how these affect health. The need to better understand aging is amplified by demographic changes, which have caused a gradual increase in the global population of older people. Aging western populations have resulted in a rise in the prevalence of age-related pathologies. Of these diseases, cardiovascular disease is the most common underlying condition in older people. The dysregulation of lipid metabolism due to aging impinges significantly on cardiovascular health. However, the multifaceted nature of lipid metabolism and the complexities of its interaction with aging make it challenging to understand by conventional means. To address this challenge computational modeling, a key component of the systems biology paradigm is being used to study the dynamics of lipid metabolism. This mini-review briefly outlines the key regulators of lipid metabolism, their dysregulation, and how computational modeling is being used to gain an increased insight into this system.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlwww.elsevier.com/locate/csbjen
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S2001037014000476en
dc.rightsArchived with thanks to Computational and Structural Biotechnology Journalen
dc.subjectageingen
dc.subjectcomputer modellingen
dc.titleComputationally modeling lipid metabolism and aging: A mini-reviewen
dc.typeArticleen
dc.contributor.departmentUniversity of Chester ; Edge Hill Universityen
dc.identifier.journalComputational and Structural Biotechnology Journalen
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