Mortality in type 2 diabetes mellitus: Magnitude of the evidence from a systematic review and meta-analysis

Hdl Handle:
http://hdl.handle.net/10034/336032
Title:
Mortality in type 2 diabetes mellitus: Magnitude of the evidence from a systematic review and meta-analysis
Authors:
Nwaneri, Chukwuemeka; Cooper, Helen; Bowen-Jones, David
Abstract:
Type 2 diabetes is associated with an increase in age-related mortality. A systematic review and metaanalysis were performed to define the relative risks (RR) of all-cause or cause-specific mortality in type 2 diabetes and to determine gaps in current research. A comprehensive literature search was undertaken for studies (published 1990–2010) on mortality in type 2 diabetes. The study reports on the measure of mortality as defined by RR for all-cause and cause-specific mortality, heterogeneity, sensitivity analyses and biases. In total 35 studies (220,689 patients; mean follow-up of 10.7 years) were eligible for inclusion: 33 studies reported increased mortality risks; 24 had full data on 95% confidence intervals (CIs), one study reported no excess mortality in men diagnosed after 65 years whereas three reported increased mortality in similar age groups in both sexes. Meta-analysis showed RR = 1.85 (95% CI 1.79–1.92) for all-cause mortality [men RR=1.57 (95% CI 1.46–1.68); women RR=2.0 (95% CI 1.89–2.12)], RR=1.76 (95% CI 1.66–1.88) for cardiovascular mortality and RR=2.26 (95% CI: 1.7-3.02) for stroke. There was no statistically significant evidence of publication bias. Conclusion: Type 2 diabetes increases mortality approximately two-fold increase and macrovascular disease is the principal cause of death.
Affiliation:
University of Chester ; University of Chester ; Alder Hey Children’s NHS Foundation Trust
Citation:
British Journal of Diabetes & Vascular Disease, 2013, 13(4), pp.192-207
Publisher:
SAGE
Journal:
British Journal of Diabetes & Vascular Disease
Publication Date:
2013
URI:
http://hdl.handle.net/10034/336032
DOI:
10.1177/1474651413495703
Additional Links:
http://dvd.sagepub.com
Type:
Article
Language:
en
Description:
This article is not available through ChesterRep.
ISSN:
1474-6514
EISSN:
1753-4305
Appears in Collections:
Health and Social Care

Full metadata record

DC FieldValue Language
dc.contributor.authorNwaneri, Chukwuemekaen
dc.contributor.authorCooper, Helenen
dc.contributor.authorBowen-Jones, Daviden
dc.date.accessioned2014-11-24T11:19:55Zen
dc.date.available2014-11-24T11:19:55Zen
dc.date.issued2013en
dc.identifier.citationBritish Journal of Diabetes & Vascular Disease, 2013, 13(4), pp.192-207en
dc.identifier.issn1474-6514en
dc.identifier.doi10.1177/1474651413495703en
dc.identifier.urihttp://hdl.handle.net/10034/336032en
dc.descriptionThis article is not available through ChesterRep.en
dc.description.abstractType 2 diabetes is associated with an increase in age-related mortality. A systematic review and metaanalysis were performed to define the relative risks (RR) of all-cause or cause-specific mortality in type 2 diabetes and to determine gaps in current research. A comprehensive literature search was undertaken for studies (published 1990–2010) on mortality in type 2 diabetes. The study reports on the measure of mortality as defined by RR for all-cause and cause-specific mortality, heterogeneity, sensitivity analyses and biases. In total 35 studies (220,689 patients; mean follow-up of 10.7 years) were eligible for inclusion: 33 studies reported increased mortality risks; 24 had full data on 95% confidence intervals (CIs), one study reported no excess mortality in men diagnosed after 65 years whereas three reported increased mortality in similar age groups in both sexes. Meta-analysis showed RR = 1.85 (95% CI 1.79–1.92) for all-cause mortality [men RR=1.57 (95% CI 1.46–1.68); women RR=2.0 (95% CI 1.89–2.12)], RR=1.76 (95% CI 1.66–1.88) for cardiovascular mortality and RR=2.26 (95% CI: 1.7-3.02) for stroke. There was no statistically significant evidence of publication bias. Conclusion: Type 2 diabetes increases mortality approximately two-fold increase and macrovascular disease is the principal cause of death.en
dc.language.isoenen
dc.publisherSAGEen
dc.relation.urlhttp://dvd.sagepub.comen
dc.rightsArchived with thanks to The British Journal of Diabetes & Vascular Diseaseen
dc.subjectmeta-analysisen
dc.subjectmortality rateen
dc.subjectodds ratioen
dc.subjectrelative risken
dc.subjecttype 2 diabetes mellitusen
dc.titleMortality in type 2 diabetes mellitus: Magnitude of the evidence from a systematic review and meta-analysisen
dc.typeArticleen
dc.identifier.eissn1753-4305en
dc.contributor.departmentUniversity of Chester ; University of Chester ; Alder Hey Children’s NHS Foundation Trusten
dc.identifier.journalBritish Journal of Diabetes & Vascular Diseaseen
All Items in ChesterRep are protected by copyright, with all rights reserved, unless otherwise indicated.