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ChesterRep is the University of Chester's institutional repository and an online platform designed to collate, store, and aid discoverability of research carried out at the university to the wider research community
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Seismic Design of Offshore Wind Turbines: Good, Bad and UnknownsLarge scale offshore wind farms are relatively new infrastructures and are being deployed in regions prone to earthquakes. Offshore wind farms comprise of both offshore wind turbines (OWTs) and balance of plants (BOP) facilities, such as inter-array and export cables, grid connection etc. An OWT structure can be either grounded systems (rigidly anchored to the seabed) or floating systems (with tension legs or catenary cables). OWTs are dynamically-sensitive structures made of a long slender tower with a top-heavy mass, known as Nacelle, to which a heavy rotating mass (hub and blades) is attached. These structures, apart from the variable environmental wind and wave loads, may also be subjected to earthquake related hazards in seismic zones. The earthquake hazards that can affect offshore wind farm are fault displacement, seismic shaking, subsurface liquefaction, submarine landslides, tsunami effects and a combination thereof. Procedures for seismic designing OWTs are not explicitly mentioned in current codes of practice. The aim of the paper is to discuss the seismic related challenges in the analysis and design of offshore wind farms and wind turbine structures. Different types of grounded and floating systems are considered to evaluate the seismic related effects. However, emphasis is provided on Tension Leg Platform (TLP) type floating wind turbine. Future research needs are also identified.
Effect of massage therapy on pain and quality of life in dogs: A cross sectional studyAbstract: Background: Clinical canine massage involves muscle tissue manipulation and fascial release techniques to rehabilitate injured soft tissues. Quantitative efficacy data are lacking. This cross‐sectional study aimed to determine how dogs respond to canine massage therapy practiced by Canine Massage Guild UK practitioners. Methods: In 2018, case notes from a convenience sample of 527 dogs were shared, with permission from owners, by a self‐selected sample of 65 practitioners. Changes in number and severity of issues for five pain indicators (gait, posture, daily activity, behaviour, performance) and quality of life score, reported by owner and practitioners, were investigated. Results: Significant reductions in reported pain severity scores were recorded for all pain indicators over successive treatments (p < 0.001), with each treatment causing further significant reduction in pain severity. Number of pain indicators recorded over successive treatment sessions remained constant, in keeping with a cohort presenting with degenerative disease and chronic pain. All dogs and diagnostic variables responded similarly. Post‐treatment a dog was significantly more likely to have a ‘positive’ quality of life. Conclusions: This cross‐sectional study indicates canine massage therapy may effectively reduce myofascial and musculoskeletal pain severity reported by owners and practitioners associated with gait, posture, behavioural and performance issues and reduction in daily activities. Although this is not a double‐blind trial, and there is no control group, this study suggests massage therapy may be a valid treatment for myofascial and musculoskeletal pain typically derived from muscular injuries, arthritis/other orthopaedic conditions.
PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions.Charge is a key determinant of intrinsically disordered protein (IDP) and intrinsically disordered region (IDR) properties. IDPs and IDRs are enriched in sites of phosphorylation, which alters charge. Visualizing the degree to which phosphorylation modulates the charge profile of a sequence would assist in the functional interpretation of IDPs and IDRs. PhosIDP is a web tool that shows variation of charge and fold propensity upon phosphorylation. In combination with the displayed location of protein domains, the information provided by the web tool can lead to functional inferences for the consequences of phosphorylation. IDRs are components of many proteins that form biological condensates. It is shown that IDR charge, and its modulation by phosphorylation, is more tightly controlled for proteins that are essential for condensate formation than for those present in condensates but inessential.
Underlying Thinking Pattern Profiles Predict Parent-Reported Distress Responses in Autism Spectrum Disorder.Appreciating autistic neurodiversity is important when supporting autistic people who experience distress. Specifically, use of a profiling model can reveal less visible autistic differences, including strengths and abilities. Binary logistic regressions showed that the likelihood of extreme distress responses could be interpreted based on parent-reported autistic thinking pattern profiles for 140 young people. Perspective-taking (specifically empathy), extreme demand avoidance, and over-sensory sensitivity each contributed to the combined regression models. From the clinical perspective of autism as a multi-dimensional and inter-connected construct, there may be implications for planning support and building positive self-understanding. Individually tailored adjustments and support strategies may be identified more easily after delineating variables found across four core aspects: sensory coherence, flexible thinking, perspective-taking, and regulation.