Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease

Hdl Handle:
http://hdl.handle.net/10034/70457
Title:
Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease
Authors:
McCaddon, Andrew; Bleenow, Kaj; Hudson, Peter R.; Hughes, Alan; Barber, Joan; Gray, Rob; Davies, Gareth K.; Williams, John H. H.; Duguid, Jennifer; Lloyd, Alwyn; Tandy, Steve; Everall, Marge; Cattell, Howard; McCaddon, Anne; Ellis, Dick; Palmer, Mona; Bogdanovic, Nenad; Gottfires, Carl-Gerhard; Zetterberg, Henrik; Rymo, Lars; Regland, Bjorn
Abstract:
Isoforms of the vitamin B<12< carrier protein transcobalamin (TC) might influence its cellular availability and contribute to the association between disrupted single-carbon metabolism and Alzheimer's disease (AD). We therefore investigated the relationships between the TC 776C>G (Pro259Arg) genetic polymorphism, total serum cobalamin and holo-TC levels, and disease onset in 70 patients with clinically diagnosed AD and 74 healthy elderly controls. TC 776C>G polymorphism was also determined for 94 histopathologically confirmed AD patients and 107 controls. Serum holo-TC levels were significantly higher in TC 776C homozygotes (p = 0.04). Kaplan-Meier survival functions differed between homozygous genotypes (Cox's F-Test F(42, 46) = 2.1; p = 0.008) and between 776C homozygotes and heterozygotes (Cox's F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study.
Affiliation:
University of Wales College of Medicine ; University of Goteborg ; Wrexham Maelor Hospital ; Royal Alexandra Hospital, Paisley ; Garnock Day Hospital/Ayrshire Central Hospital, Irvine ; Royal Alexandra Hospital, Paisley ; Wrexham Maelor Hospital ; University College Chester ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; University of Wales College of Medicine ; University Hospital of Wales, Cardiff ; University of Goteborg ; Huddinge University Hospital, Stockholm ; University of Goteborg ; University of Goteborg ; University of Goteborg ; University of Goteborg
Citation:
Dementia and Geriatric Cognitive Disorders, 2004, 17(3), pp. 215-221.
Publisher:
S. Karger AG
Journal:
Dementia and Geriatric Cognitive Disorders
Publication Date:
2004
URI:
http://hdl.handle.net/10034/70457
DOI:
10.1159/000076359
Additional Links:
http://www.karger.com
Type:
Article
Language:
en
Description:
This article is not available through ChesterRep.
ISSN:
1420-8008; 1421-9824
Sponsors:
This article was submitted to the RAE2008 for the University of Chester - Allied Health Professions and Studies.
Appears in Collections:
Biological Sciences

Full metadata record

DC FieldValue Language
dc.contributor.authorMcCaddon, Andrewen
dc.contributor.authorBleenow, Kajen
dc.contributor.authorHudson, Peter R.en
dc.contributor.authorHughes, Alanen
dc.contributor.authorBarber, Joanen
dc.contributor.authorGray, Roben
dc.contributor.authorDavies, Gareth K.en
dc.contributor.authorWilliams, John H. H.en
dc.contributor.authorDuguid, Jenniferen
dc.contributor.authorLloyd, Alwynen
dc.contributor.authorTandy, Steveen
dc.contributor.authorEverall, Margeen
dc.contributor.authorCattell, Howarden
dc.contributor.authorMcCaddon, Anneen
dc.contributor.authorEllis, Dicken
dc.contributor.authorPalmer, Monaen
dc.contributor.authorBogdanovic, Nenaden
dc.contributor.authorGottfires, Carl-Gerharden
dc.contributor.authorZetterberg, Henriken
dc.contributor.authorRymo, Larsen
dc.contributor.authorRegland, Bjornen
dc.date.accessioned2009-06-15T11:29:28Zen
dc.date.available2009-06-15T11:29:28Zen
dc.date.issued2004en
dc.identifier.citationDementia and Geriatric Cognitive Disorders, 2004, 17(3), pp. 215-221.en
dc.identifier.issn1420-8008en
dc.identifier.issn1421-9824en
dc.identifier.doi10.1159/000076359en
dc.identifier.urihttp://hdl.handle.net/10034/70457en
dc.descriptionThis article is not available through ChesterRep.en
dc.description.abstractIsoforms of the vitamin B<12< carrier protein transcobalamin (TC) might influence its cellular availability and contribute to the association between disrupted single-carbon metabolism and Alzheimer's disease (AD). We therefore investigated the relationships between the TC 776C>G (Pro259Arg) genetic polymorphism, total serum cobalamin and holo-TC levels, and disease onset in 70 patients with clinically diagnosed AD and 74 healthy elderly controls. TC 776C>G polymorphism was also determined for 94 histopathologically confirmed AD patients and 107 controls. Serum holo-TC levels were significantly higher in TC 776C homozygotes (p = 0.04). Kaplan-Meier survival functions differed between homozygous genotypes (Cox's F-Test F(42, 46) = 2.1; p = 0.008) and between 776C homozygotes and heterozygotes (Cox's F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study.en
dc.description.sponsorshipThis article was submitted to the RAE2008 for the University of Chester - Allied Health Professions and Studies.en
dc.language.isoenen
dc.publisherS. Karger AGen
dc.relation.urlhttp://www.karger.comen
dc.subjectvitamin B12en
dc.subjectAlzheimer's diseaseen
dc.subjectholo-transcobaliaminen
dc.titleTranscobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's diseaseen
dc.typeArticleen
dc.contributor.departmentUniversity of Wales College of Medicine ; University of Goteborg ; Wrexham Maelor Hospital ; Royal Alexandra Hospital, Paisley ; Garnock Day Hospital/Ayrshire Central Hospital, Irvine ; Royal Alexandra Hospital, Paisley ; Wrexham Maelor Hospital ; University College Chester ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; University of Wales College of Medicine ; University Hospital of Wales, Cardiff ; University of Goteborg ; Huddinge University Hospital, Stockholm ; University of Goteborg ; University of Goteborg ; University of Goteborg ; University of Goteborgen
dc.identifier.journalDementia and Geriatric Cognitive Disordersen
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