Folate supplementation reduces serum Hsp70 levels in patients with type 2 diabetes

Hdl Handle:
http://hdl.handle.net/10034/69797
Title:
Folate supplementation reduces serum Hsp70 levels in patients with type 2 diabetes
Authors:
Hunter-Lavin, Claire; Hudson, Peter R.; Mukhergee, Sagarika; Davies, Gareth K.; Williams, Clive P.; Harvey, John N.; Child, David F.; Williams, John H. H.
Abstract:
Type 2 diabetes patients are subject to oxidative stress as a result of hyperglycemia. The aim of this study was to determine whether administration of the antioxidant folic acid, previously shown to reduce homocysteine levels, would reduce circulating levels of Hsp70 while improving the condition of type 2 diabetes patients with microalbuminuria. Plasma homocysteine fell from pretreatment values of 12.9 to 10.3 μM (P < 0.0001). The urine albumin-creatinine ratio fell from 12.4 to 10.4 mg/mM (P = 0.38). Pretreatment Hsp70 levels were higher in patients not taking insulin (5.32 ng/mL) compared with those on insulin (2.44 ng/mL) (P = 0.012). Folic acid supplementation resulted in a significant fall in Hsp70 (5.32 to 2.05 ng/mL) (P = 0.004). There was no change in Hsp70 in those receiving insulin. Folic acid supplementation in non–insulin-treated type 2 diabetes patients, therefore, resulted in a fall in Hsp70, reflecting an improvement in oxidative stress. The data shows that improvement in homocysteine status can lead to a reduction in Hsp70, indicating the possibility of its use as a marker for severity of disease.
Affiliation:
University College Chester ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; University College Chester
Citation:
Cell Stress Chaperones, 9(4), 2004, pp. 344–349
Publisher:
Cell Stress Society International
Journal:
Cell Stress Chaperones
Publication Date:
Oct-2004
URI:
http://hdl.handle.net/10034/69797
DOI:
10.1379/CSC-28R.1.
Additional Links:
http://www.springer.com/biomed/journal/12192
Type:
Article
Language:
en
Description:
This article is not available through ChesterRep. It is available through PubMed Central http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1065273
ISSN:
1355-8145
Appears in Collections:
Biological Sciences

Full metadata record

DC FieldValue Language
dc.contributor.authorHunter-Lavin, Claireen
dc.contributor.authorHudson, Peter R.en
dc.contributor.authorMukhergee, Sagarikaen
dc.contributor.authorDavies, Gareth K.en
dc.contributor.authorWilliams, Clive P.en
dc.contributor.authorHarvey, John N.en
dc.contributor.authorChild, David F.en
dc.contributor.authorWilliams, John H. H.en
dc.date.accessioned2009-06-05T16:19:10Zen
dc.date.available2009-06-05T16:19:10Zen
dc.date.issued2004-10en
dc.identifier.citationCell Stress Chaperones, 9(4), 2004, pp. 344–349en
dc.identifier.issn1355-8145en
dc.identifier.doi10.1379/CSC-28R.1.en
dc.identifier.urihttp://hdl.handle.net/10034/69797en
dc.descriptionThis article is not available through ChesterRep. It is available through PubMed Central http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1065273en
dc.description.abstractType 2 diabetes patients are subject to oxidative stress as a result of hyperglycemia. The aim of this study was to determine whether administration of the antioxidant folic acid, previously shown to reduce homocysteine levels, would reduce circulating levels of Hsp70 while improving the condition of type 2 diabetes patients with microalbuminuria. Plasma homocysteine fell from pretreatment values of 12.9 to 10.3 μM (P < 0.0001). The urine albumin-creatinine ratio fell from 12.4 to 10.4 mg/mM (P = 0.38). Pretreatment Hsp70 levels were higher in patients not taking insulin (5.32 ng/mL) compared with those on insulin (2.44 ng/mL) (P = 0.012). Folic acid supplementation resulted in a significant fall in Hsp70 (5.32 to 2.05 ng/mL) (P = 0.004). There was no change in Hsp70 in those receiving insulin. Folic acid supplementation in non–insulin-treated type 2 diabetes patients, therefore, resulted in a fall in Hsp70, reflecting an improvement in oxidative stress. The data shows that improvement in homocysteine status can lead to a reduction in Hsp70, indicating the possibility of its use as a marker for severity of disease.en
dc.language.isoenen
dc.publisherCell Stress Society Internationalen
dc.relation.urlhttp://www.springer.com/biomed/journal/12192en
dc.subjecttype 2 diabetesen
dc.subjectantioxidant folic aciden
dc.titleFolate supplementation reduces serum Hsp70 levels in patients with type 2 diabetesen
dc.typeArticleen
dc.contributor.departmentUniversity College Chester ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; University College Chesteren
dc.identifier.journalCell Stress Chaperonesen
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