Structural characterisation of two pharmaceutically important steroids by solid-state NMR

Hdl Handle:
http://hdl.handle.net/10034/68039
Title:
Structural characterisation of two pharmaceutically important steroids by solid-state NMR
Authors:
Othman, Abdullah; Harris, Robin K; Hodgkinson, Paul; Christopher, Elizabeth A; Lancaster, Robert W
Abstract:
Several crystal modifications of two steroids (androsterone and beclomethasone dipropionate) have been characterised by solid-state NMR methods, and the chemical shifts between the different forms compared. The gradual loss of water from androsterone hemihydrate has been monitored by XRPD. The crystal structures are discussed in relation to the NMR data. That of the beclomethasone dipropionate ethyl acetate solvate has been determined for the first time. It is found that there are clear channels containing the ethyl acetate molecules, which are apparently not incorporated by hydrogen bonding. Carbon-13 CPMAS spectra with long contact times and MAS proton spectra are used to show the mobility of ethyl acetate molecules in the BDP solvate. The second-order effect of chlorine on the 13C spectrum of beclomethasone dipropionate monohydrate has been explored by varying the applied magnetic field.
Affiliation:
University of Durham ; University of Durham ; University of Durham ; University of Chester/University of Durham ; University of Durham
Citation:
New Journal of Chemistry, 32, (2008), pp. 1796-1806
Publisher:
Royal Society of Chemistry/Centre National de la Recherche Scientifique
Journal:
New Journal of Chemistry
Issue Date:
2008
URI:
http://hdl.handle.net/10034/68039
DOI:
10.1039/b803586e
Additional Links:
http://www.rsc.org/njc
Type:
Article
Language:
en
Description:
This article is not available through ChesterRep.
ISSN:
11440546; 13699261
Appears in Collections:
The Graduate School

Full metadata record

DC FieldValueLanguage
dc.contributor.authorOthman, Abdullah-
dc.contributor.authorHarris, Robin K-
dc.contributor.authorHodgkinson, Paul-
dc.contributor.authorChristopher, Elizabeth A-
dc.contributor.authorLancaster, Robert W-
dc.date.accessioned2009-05-13T15:43:52Z-
dc.date.available2009-05-13T15:43:52Z-
dc.date.issued2008-
dc.identifier.citationNew Journal of Chemistry, 32, (2008), pp. 1796-1806en
dc.identifier.issn11440546-
dc.identifier.issn13699261-
dc.identifier.doi10.1039/b803586e-
dc.identifier.urihttp://hdl.handle.net/10034/68039-
dc.descriptionThis article is not available through ChesterRep.en
dc.description.abstractSeveral crystal modifications of two steroids (androsterone and beclomethasone dipropionate) have been characterised by solid-state NMR methods, and the chemical shifts between the different forms compared. The gradual loss of water from androsterone hemihydrate has been monitored by XRPD. The crystal structures are discussed in relation to the NMR data. That of the beclomethasone dipropionate ethyl acetate solvate has been determined for the first time. It is found that there are clear channels containing the ethyl acetate molecules, which are apparently not incorporated by hydrogen bonding. Carbon-13 CPMAS spectra with long contact times and MAS proton spectra are used to show the mobility of ethyl acetate molecules in the BDP solvate. The second-order effect of chlorine on the 13C spectrum of beclomethasone dipropionate monohydrate has been explored by varying the applied magnetic field.en
dc.language.isoenen
dc.publisherRoyal Society of Chemistry/Centre National de la Recherche Scientifiqueen
dc.relation.urlhttp://www.rsc.org/njcen
dc.titleStructural characterisation of two pharmaceutically important steroids by solid-state NMRen
dc.typeArticleen
dc.contributor.departmentUniversity of Durham ; University of Durham ; University of Durham ; University of Chester/University of Durham ; University of Durhamen
dc.identifier.journalNew Journal of Chemistryen
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